alexa Fermentative Itaconic Acid Production
ISSN: 2376-0214

Journal of Biodiversity, Bioprospecting and Development
Open Access

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Review Article

Fermentative Itaconic Acid Production

Amina Ahmed El-Imam1,2 and Chenyu Du1*
1School of Biosciences, University of Nottingham, Sutton Bonington Campus, U.K. LE12 5RD, UK
2Microbiology Department, Faculty of Life Sciences, University of Ilorin, P.M.B. 1515 Ilorin, Nigeria
*Corresponding Author : Chenyu Du
School of Biosciences, University of Nottingham
Sutton Bonington Campus, U.K. LE12 5RD, UK
Tel: +44 (0)115 95
E-mail: [email protected]
Received April 22, 2014; Accepted June 20, 2014; Published July 05, 2014
Citation: El-Imam AA, Du C (2014) Fermentative Itaconic Acid Production . J Biodivers Biopros Dev 1:119. doi:10.4172/2376-0214.1000119
Copyright: © 2014 El-Imam AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Itaconic acid is an organic acid that is used as a platform chemical for the production of various value added chemicals such as poly-itaconic acid, resins biofuel components, ionomer cements etc. Itaconic acid and its derivatives have wide applications in the textile, chemical and pharmaceutical industries. The depletion of fossil fuels and the need for sustainable development require that fermentative itaconic acid production replace petroleumbased methods of itaconic acid production. Various microorganisms have been employed in itaconic acid fermentations, with the most prolific producer being Aspergillus terreus. Over 80 g/L itaconic acid has been produced in fermentations using glucose. However, there is an increasing interest in the utilization of lignocellulosic materials for itaconic acid production due to the concern of food security. This review summarizes the latest progress in fermentative itaconic acid production with emphasis on the different species and strains of microorganisms used, substrate types and fermentation conditions. The current industrial applications of itaconic acid and its potential use as a drop-in or novel substitute monomer to replace petroleum-based chemicals were also extensively explored. Recent trends in itaconic acid research summarized in this review paper indicate that itaconic acid can be produced cost effectively from sustainable raw materials and have the potential to replace petro-based chemicals in various applications.

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