alexa Fermented Medicinal Plant Designed by Lactobacillus Hits Alternative Complement Pathway and Controlled hA1c Level | OMICS International
ISSN: 2329-6836

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Research Article

Fermented Medicinal Plant Designed by Lactobacillus Hits Alternative Complement Pathway and Controlled hA1c Level

Yamaguchi N1,2*, Akazawa-Kudoh S3, Sawada M3, Fujimoto Y3 and Murayama T4

1Ishikawa Natural Medicinal Products Research Center, Ishikawa, Japan

2Department of Fundament Research for CAM, Kanazawa Medical University, Ishikawa, Japan

3Department of General Medicine, Kanazawa Medical University, Ishikawa, Japan

4Department of Microbiology and Immunology, Faculty of Pharmaceutical Sciences, Hokuriku University, Ishikawa, 920-1181, Japan

*Corresponding Author:
Nobuo Yamaguchi
Ishikawa Natural Medicinal Products
Research Center, Ishikawa, Japan
Tel: +817622258852
E-mail: [email protected]

Received date: March 21, 2017; Accepted date: March 31, 2017; Published date: April 05, 2017

Citation: Yamaguchi N, Akazawa-Kudoh S, Sawada M, Fujimoto Y, Murayama T (2017) Fermented Medicinal Plant Designed by Lactobacillus Hits Alternative Complement Pathway and Controlled hA1c Level. Nat Prod Chem Res 5:260. doi:10.4172/2329-6836.1000260

Copyright: © 2017 Yamaguchi N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: A Type II Diabetes mellitus showed many symptoms that brought serious for the patients. One of the problem was suppressed activity of the phagocyte for the foreign microorganism.

Objective: The objective of this study was to find excellent method to recover the suppressed phagocytic cell activity both in animal and human.

Methods: A wild medicinal herbs were prepared by Yeast and Lactobaccilli against 80 sorts of wild plants including medicinal remedies (FWP80). These products were exhibited by safe in animal safety test. The trial was made to investigate a recovery of immune-competent cells both in mice and human that exhibited phagocytic depression.

Results: Our results in animal model showed that FWP80 augmented the macrophage activity, both chemotaxis and phagocytosis. In clinical study with 20 volunteers diagnosed type II DM, the granulocyte and lymphocyte ratio was produced to as modulate as neutral, 30 days after the introduction by FWP80.

Conclusion: In mice, depressed phagocytic cell by Streptozotocin, the macrophage activities were recovered by FWP80. We proposed an idea that FWP80 exhibited remedy effect via controlling complement component. The mechanism of activation was proved by activating alternative pathway of complement by the technic, immuneelectrophoresis. We tried to evaluate more to the anti-oxidative activities of FWP80, directory employing peritoneal macrophage in vivo.

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