alexa Ficolin 1 Expression is Elevated in the Peripheral Blood Mononuclear Cells of Takayasu's Vasculitis Patients
ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
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Research Article

Ficolin 1 Expression is Elevated in the Peripheral Blood Mononuclear Cells of Takayasu's Vasculitis Patients

Daisuke Okuzaki1,2, Shigeto Kobayashi3, Minami A. Sakurai1,4, Kosuke Torigata1, Ayumi Okamoto1, Toshiharu Matsumoto5, Hiroyuki Daida6, Akihiko Ito4 and Hiroshi Nojima1,2*

1Department of Molecular Genetics, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan

2DNA-chip Development Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan

3Juntendo Koshigaya Hospital, 560 Fukuroyama, Koshigaya, Saitama 343-0032, Japan

4Department of Pathology, Faculty of Medicine, Kinki University, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan

5Department of Human Pathology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421 Tokyo, Japan

6Department of Cardiovascular Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421 Tokyo, Japan

*Corresponding Author:
Hiroshi Nojima
DNA-chip Development Center for Infectious Diseases
Research Institute for Microbial Diseases, Osaka University
3-1 Yamadaoka, Suita, Osaka 565-0871, Japan, Juntendo Koshigaya Hospital
560 Fukuroyama, Koshigaya, Saitama 343-0032, Japan
Tel: +81-6-6875-3980
Fax: +81-6-6875-5192
E-mail: [email protected]

Received date: February 22, 2012; Accepted date: March 27, 2012; Published date: April 06, 2012

Citation: Okuzaki D, Kobayashi S, Sakurai MA, Torigata K, Okamoto A, et al. (2012) Ficolin 1 Expression is Elevated in the Peripheral Blood Mononuclear Cells of Takayasu’s Vasculitis Patients. J Mol Biomark Diagn 2:125. doi:10.4172/2155-9929.1000125

Copyright: © 2012 Okuzaki D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Takayasu’s arteritis (TA), a form of vasculitis (angiitis), is a chronic inflammatory disease involving the large blood vessels. This study reports the identification of genes showing increased mRNA levels in peripheral blood mononuclear cells (PBMCs) from TA patients regardless of symptoms or disease activity/inactivity. Of these, mRNA for Ficolin 1 (FCN1) showed a four-fold increase in all eight TA patients examined. Increased FCN1 mRNA levels observed in cDNA microarrays were confirmed by quantitative reverse transcription polymerase chain reaction. Increased FCN1 protein expression was also observed in inflamed regions of the surgical aorta specimens. Moreover, most FCN1-positive cells were also positive for CD68, indicating the presence of monocytic cells, such as macrophages or dendritic cells, which attack infectious agents within the inflamed regions. Taken together, the results suggest that FCN1 mRNA levels in peripheral blood samples may be a diagnostic marker for TA.

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