alexa Fish Oil Prophylaxis Protects against 3-Nitropropinic Acid-Induced Oxidative Impairments in Striatum and Cerebellum in Male Rat Brain
ISSN: 2469-9780

Neurochemistry & Neuropharmacology
Open Access

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Research Article

Fish Oil Prophylaxis Protects against 3-Nitropropinic Acid-Induced Oxidative Impairments in Striatum and Cerebellum in Male Rat Brain

Denny Joseph Manual Kollareth1*, Denny Joseph Manual Kollareth2, MM Srinivas Bharath2, and Muralidhara1

1Department of Biochemistry, CSIR - Central Food Technological Research Institute (CFTRI), Mysuru, Karnataka, India

2Department of Neurochemistry, National Institute of Mental Health and Neurosciences (NIMHANS), Bengaluru, Karnataka, India

*Corresponding Author:
Denny Joseph Manual Kollareth
Institute of Human Nutrition, Columbia University Medical Center
NY, New York
Tel: +12123053961
Fax: +12123056772
E-mail: [email protected]

Received date: April 24, 2017; Accepted date: May 03, 2017; Published date: May 08, 2017

Citation: Kollareth DJM, Babu MR, Bharath MMS, Muralidhara M (2017) Fish Oil Prophylaxis Protects against 3-Nitropropinic Acid-Induced Oxidative Impairments in Striatum and Cerebellum in Male Rat Brain. Neurochem Neuropharm 3: 116. doi: 10.4172/2469-9780.1000116

Copyright: © 2017 Kollareth DJM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Increasing evidence supports a role for fish oil (FO) and the n-3 polyunsaturated fatty acids (n-3 PUFA) -docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), in protecting against neurodegeneration. However, experimental evidence on their neuroprotective efficacy in neurotoxin models is rather limited. In the present study, we examined whether pretreatment with n-3 PUFA in SH-SY5Y cells and FO prophylaxis in rats would render them less susceptible to 3-nitropropionic acid (a mitochondrial toxin, NPA) exposure. Cells pretreated with DHA/EPA were more resistant to NPA-induced perturbations in antioxidant defenses and exhibited higher survival rate. Further, we validated these findings among growing rats provided with FO (4 mL/kg bw) prophylaxis for 4 weeks and subjected to NPA challenge (25 mg/kg bw/d during last 4 d). Interestingly, FO prophylaxis offered significant protection against NPA -induced oxidative dysfunctions and depleted dopamine levels in striatum. Based on our in vitro and in vivo findings, we hypothesize that the protective effect of FO may be wholly or in part related to its potential to enhance GSH, thiols and antioxidant defenses in specific regions of brain of rats. Thus FO prophylaxis is likely to offer a therapeutic advantage as a neuroprotective strategy under oxidative stress-mediated neurodegenerative conditions.


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