alexa Fish Oil Supplementation Ameliorated Brain Lesions Induced by Diabetes and Hypercholesterolemia in Male Wistar Albino Rats
ISSN: 2165-7890

Autism-Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Fish Oil Supplementation Ameliorated Brain Lesions Induced by Diabetes and Hypercholesterolemia in Male Wistar Albino Rats

Hassan IH El Sayyad1*, Iman HM Bakr1, Ahmed A El Mansi1, Ali H amin1,2, Mohamed E El Beeh1,2, Adel MA Asiri2
1Zoology Department, Faculty of Science, Mansoura University, Egypt
2Institiute of Scientific Research and Revival of Islamic Heritage, Um Al-Qura University, Mecca, kingdom Saudi Arabia
Corresponding Author : Hassan IH El Sayyad
Faculty of Science
Mansoura University
Mansoura, Egypt
Tel: 0020502254850
E-mail: elsayyad@mans.edu.eg
Received: July 30, 2015; Accepted: August 31, 2015; Published: September 07, 2015
Citation: El Sayyad HIH, Bakr IHM, El Mansi AA, Amin AH, El Beeh ME, et al. (2015) Fish Oil Supplementation Ameliorated Brain Lesions Induced by Diabetes and Hypercholesterolemia in Male Wistar Albino Rats. Autism Open Access 5:148. doi:10.4172/2165-7890.1000148
Copyright: © 2015 El Sayyad HIH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at Pubmed, Scholar Google
 

Abstract

Diabetes and hypercholesterolemia are dyslipidemic diseases and have certain role in brain dysfunction, but little of works are concerning with it. In the present study we used eighty male Wistar rats weighing approximately 100 ±15 gram. The animals were arranged into 8 groups; Control (C), fish oil-treatment, hypercholesterolemic group (H), hypercholesterolemic & fish oil-treatment (HF), diabetic- group (D), diabetic and fish oil-treatment (DF), combined hypercholesterolemic and diabetic group (HD) and combined hypercholesterolemic and diabetic group and fish-oil-treatment (HDF). Diabetes was induced by streptozotocin (40mg/kg single dose in citrate buffer pH4.6). Hypercholesterolemia was carried out by feeding rats on diet containin3% cholesterol. Fish oil (Menhaden, Sigmaaldrich, highest purity) was supplemented orally every other day at 100mg/kg body weight. Treatment was carried out for 16 weeks. At the end of treatment, brain tissues were subjected for histological investigation and biochemical assessments of dopamine, serotonin, vascular endothelial growth factor, 8-deoxyhydroxy-guanosine, adhesion molecules and phospholipids beside histological investigation of cerebral hemisphere and cerebellum. The present finding revealed marked depletion of the assayed neurotransmitters and phospholipids and increased of vascular endothelial growth factor, adhesion molecules and 8-deoxy hydroxy-guanosine. Histological observations of cerebral hemisphere revealed widespread of hemorrhagic spots in hypercholesterolemia, neovascualarization in combined diabetes and hypercholesterolemia and dense lymphocytic infiltration in diabetic group. All the experimental groups possessed edematous lesions in the inner plexiform layer. Cerebellar cortex exhibited massive degeneration of Purkinje cells and granular cell layer in diabetic and or hypercholesterolemia. Fish oil supplementation improved the brain function and histological picture. The authors concluded that fish oil contain short and long chain omega-3 fatty acids fatty acid which support the brain function and scavenge the free radicals damaging brain cells.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords