alexa Fishing for Precision in ALK-Rearranged Non-Small-Cell Lung Cancers | OMICS International | Abstract
ISSN: 2471-8556

Oncology & Cancer Case Reports
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Case Report

Fishing for Precision in ALK-Rearranged Non-Small-Cell Lung Cancers

Xiuning Le1, Mary Linton Peters1, Paul A VanderLaan2, Daniel B Costa1 and Deepa Rangachari1*
1Department of Medicine, Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
2Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Corresponding Author : Deepa Rangachari
Division of Hematology/Oncology
Beth Israel Deaconess Medical Center
330 Brookline Avenue, Shapiro 9 Boston
MA 02215, United states
Tel: 617-667-1580
Fax: 617-667-2518
E-mail: [email protected].edu
Received: October 22, 2015; Accepted: December 03, 2015; Published: December 07, 2015
Citation:Le X, Peters ML, VanderLaan PA, Costa DB, Rangachari D (2015) Fishing for Precision in ALK-Rearranged Non-Small-Cell Lung Cancers. Oncol Cancer Case Rep 1:105. doi:10.4172/2471-8556.1000105
Copyright: © 2015 Le X, et al.. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) represent the current standard for identification of therapeutically relevant anaplastic lymphoma kinase (ALK) rearrangements in advanced non-small-cell lung cancers (NSCLCs). Use of tyrosine kinase inhibitors (TKIs) targeting the oncogenic ALK fusion protein is approved for use in advanced ALK-rearranged NSCLCs and with benefits both with regards to clinical outcomes and quality of life when compared with traditional palliative cytotoxic therapies. We report here 2 cases in which initial standard of care ALK testing by FISH yielded false positive results, leading to delays in determination of optimal systemic therapy.

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