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Florid Endocervical Microglandular Hyperplasia in Association with Tamoxifen Treatment | OMICS International | Abstract
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

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Case Report

Florid Endocervical Microglandular Hyperplasia in Association with Tamoxifen Treatment

Ayakannu T1, Hew WSR2, Brown L2, Ismail S3, Maulik TG4, Kiberu SW2and Taylor AH1,5*

1Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK

2University Hospitals of Leicester NHS Trust, Pathology Department, Leicester, UK

3University Hospital of South Manchester NHS Foundation Trust, M23 9LT, UK

4Department of Obstetrics and Gynaecology, Prince Charles Hospital, Merthyr Tydfil, South Wales, CF47 9DT, UK

5Biosciences, School of Science and Technology, Nottingham Trent University, Clifton Campus, Nottinghamshire, UK

*Corresponding Author:
Anthony H Taylor
Biosciences, School of Science and Technology
Nottingham Trent University
Clifton Campus, Nottinghamshire, UK
Tel: +44 01158485322
E-mail: [email protected]

Received Date: August 04, 2015 Accepted Date: October 13, 2015 Published Date: October 15, 2015

Citation:Ayakannu T, Hew WSR, Brown L, Ismail S, Maulik TG, et al. (2015) Florid Endocervical Microglandular Hyperplasia in Association with Tamoxifen Treatment. J Cytol Histol 6:375. doi:10.4172/2157-7099.1000375

Copyright: ©2015, Ayakannu T et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited..


Background: Although tamoxifen has well documented oestrogen-like effects in the endometrium and ectocervical squamous epithelium, its effects on the endocervix are poorly documented.
Case report: We report a case of an 88 year-old woman who presented with postmenopausal bleeding after receiving tamoxifen for 16 months following a diagnosis of Grade 2 invasive and in situ carcinoma of breast. Endometrial biopsy was performed revealing either atypical hyperplasia or adenocarcinoma. She underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy and lymph gland sampling. Histopathological examination of the uterus showed an endometrioid carcinoma (FIGO Grade 2) at the endometrium. In addition, there was extensive florid endocervical microglandular hyperplasia.
Conclusion: Endocervical microglandular hyperplasia is usually seen in woman of reproductive age, particularly in association with pregnancy and contraceptive use. It is unusual in postmenopausal woman and its presence in this 88 year-old tamoxifentreated patient implicates tamoxifen as a course of endocervical microglandular hyperplasia in this instance.