alexa Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Review Article

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

Beata Miksa*

Centre of Molecular and Macromolecular Studies, Polish Academy of Science, Lodz Sienkiewicza, Poland

*Corresponding Author:
Beata Miksa
Centre of Molecular and Macromolecular Studies
Polish Academy of Science, Lodz Sienkiewicza 112, 90-363, Poland
Tel: +48426815832
E-mail: [email protected]

Received date: October 22, 2016; Accepted date: November 12, 2016; Published date: November 15, 2016

Citation: Miksa B (2016) Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy. Med Chem (Los Angeles) 6:611-639. doi:10.4172/2161-0444.1000406

Copyright: © 2016 Miksa B. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

This review highlights the role of fluorescent dyes as active “molecular photoswiches” focusing on the application in bioimaging and anticancer therapies in the field of therapeutic delivery. The author describes the development of prodrugs targeted to specific cell types and polymeric nanocarriers (capsules, micelles and silica nanoparticles) used as fluorescent probes which offer advantages in the integration of “smart” features of fluorescent dyes into synthetic materials. The incorporation of biologically responsive components that cleave upon changes in pH or light irradiation is fundamental to the successful design of such carriers with capabilities to load and release therapeutics specifically at a target site.

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