alexa Fluoride Induces Morphological and Biochemical Changes in Goat Eye Lens
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
Open Access

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Research Article

Fluoride Induces Morphological and Biochemical Changes in Goat Eye Lens

Sudhanshu Mishra1,2, Swati Tomar1,3, Anant Sharma1,3, Dushyant Singh Chauhan1,2 and Sandeep Tripathi1,2*
1 National Referral Centre for Fluoride poisoning in India, Nims University, Jaipur, India
2 Department of Advanced Sciences & Biotechnology, Nims Institute of Engineering & Technology, Nims University, Jaipur, India
3 Department of Ophthalmology, Nims Medical College, Nims University, Jaipur, India
4 Departments of Paediatrics, Nims Medical College & Hospital, Nims University, Jaipur, India
Corresponding Author : Dr. Sandeep Tripathi
Assistant Professor of Biotechnology
Head (R & D) National Referral Centre for Fluoride Poisoning in India
Nims University, Shobha Nagar, Jaipur-303121 India
Tel: +91-8955577013
E-mail: [email protected]
Received May 20, 2014; Accepted June 30, 2014; Published July 03, 2014
Citation: Mishra S, Tomar S, Sharma A, Chauhan DS, Tripathi S (2014) Fluoride Induces Morphological and Biochemical Changes in Goat Eye Lens. J Environ Anal Toxicol 4:231. doi: 10.4172/2161-0525.1000231
Copyright: © 2014 Mishra S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

In the present study, we attempted to find out the biochemical changes in goat eye lens due to Fluoride. Twenty four goat eye lenses were divided into four groups (N=6). Three experimental groups were incubated with three different concentration of Fluoride (50, 100 and 200 ppm) for 24 hours at room temperature. After incubation, lens were homogenised to estimate Lipid peroxide level (LPO), Protein carbonyl content (PC), total protein (TP), GSH and antioxidant enzymes such as SOD and CAT. We observed that gradually, LPO and PC were significantly (p<0.001) increased with the fluoride concentration while reduced glutathione level (GSH) and antioxidant enzymes, superoxidedismutase (SOD) and catalase (CAT) were significantly decreased with the increased concentration of fluoride. On the basis of the results, It may conclude that uptake of excess consumption of Fluoride may be linked with increased oxidative burden which may lead to lens opacification, progression and sometimes leads to development of cataract.

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