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FMT-PET for the Early Diagnosis of Parkinsonand#195;and#162;and#194;and#8364;and#194;and#8482;s Disease | OMICS International | Abstract
ISSN: 2329-6895

Journal of Neurological Disorders
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FMT-PET for the Early Diagnosis of Parkinson’s Disease

Sayaka Ono1,2*, Yuko Nara1, Toshihiko Sato3 and Shin-ichi Muramatsu1*
1Division of Neurology, Jichi Medical University, Tochigi, Japan
2Division of Neurology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
3Utsunomiya Central Clinic, Tochigi, Japan
Corresponding Authors : Sayaka Ono
Division of Neurology
Department of Medicine
Jichi Medical University
3311-1 Yakushiji, Shimotsuke
Tochigi 329-0498, Japan
Tel: +81-285-58-7352
Fax: +81-285-44-5118
E-mail: [email protected]
  Shin-ichi Muramatsu
Division of Neurology
Department of Medicine
Jichi Medical University
3311-1 Yakushiji, Shimotsuke
Tochigi 329-0498, Japan
Tel: +81-285-58-7352
Fax: +81-285-44-5118
E-mail: [email protected]
Received October 30, 2014; Accepted October 31, 2014; Published November 02, 2014
Citation: Ono S (2014) FMT-PET for the Early Diagnosis of Parkinson’s Disease . J Neurol Disord 2:i104. doi:10.4172/2329-6895.1000i104
Copyright: © 2014 Ono S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

A 56-year-old woman complained of a three-month history of progressive clumsiness in her left hand. She reported fine hand movements to have become slow and uncoordinated, thus leading to moderate difficulty in dressing and working as a beautician. A neurological examination revealed rigidity in her left limb. No obvious tremors were noted. She was treated with L-dopa (300 mg/day), which provided substantial symptomatic benefits. MRI showed the putamen to have a normal morphology and size, and no areas of any altered signals were observed in the brain parenchyma (Figure 1A). Positron emission tomography (PET) with an aromatic L-amino acid decarboxylase (AADC) tracer, 6-[18F] fluoro-L-m-tyrosine (FMT) showed a reduced uptake in the posterior part of the right putamen.

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