alexa Focal Epithelial Hyperplasia Prevalence in an Endemic Population, Molecular Association of HPV-13 to Asymptomatic Patients and Comparison Between Three Elementary Schools of Different Income Levels| Abstract
ISSN 2476-1966

Journal of Immunobiology
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  • Research Article   
  • J immuno Biol 2017, Vol 2(4): 133
  • DOI: 10.4172/2476-1966.1000133

Focal Epithelial Hyperplasia Prevalence in an Endemic Population, Molecular Association of HPV-13 to Asymptomatic Patients and Comparison Between Three Elementary Schools of Different Income Levels

Abraham Zavala-Garcia1*, Roberto Briceño-Mena1, Lesly Romero-Beltran1, Giorgio Alberto Franyuti Kelly2, Jose Ceron-Espinosa3 and Maria R Gonzalez- Losa1
1Virology Laboratory, Regional Research Center, Autonomous University of Yucatan, Mérida, Yucatán, Mexico
2Infectious Diseases Department, Medical IMPACT, , Mexico City, Mexico
3Dermatology Center of Yucatan, Yucatan, Yucatan Health Services (SSY), Mérida, , Yucatán, Mexico
*Corresponding Author : Abraham Zavala-Garcia, Residence of Gynecology and obstetrics, Service of Gynecology and Obstetrics, Hospital Ángeles Pedregal, Mexican Faculty of Medicine La Salle University, Road To Santa Teresa #1055, Col. Héroes De Padierna, CP 10700, Mexico City, Mexico, Tel: 55 7609-1384, Email: [email protected]

Received Date: Sep 08, 2017 / Accepted Date: Oct 26, 2017 / Published Date: Oct 30, 2017

Abstract

Heck’s disease, or Focal Epithelial Hyperplasia (FEH), caused by Human Papilloma Virus (HPV) subtypes 13 and mainly 32, is a rare and benign pathology of the oral mucosa; diagnosis is confirmed by PCR analysis.

This is a common disease in the Mayan and other Native-American populations, most frequently between 2-13 years. Risk factors include lower income class, poor hygiene and genetic predisposition.

This cross-sectional study aims to determine the prevalence of clinically compatible lesions of FEH in children from low, middle and high-income in 3 elementary schools in Yucatan, Mexico.

Clinical evaluation was conducted and documented for later analysis by a dermatologist familiar with FEH. Samples were taken and HPV-13 was identified by PCR.

The total of 186 subjects were analyzed from the low-income elementary school, with 41 subjects presenting FEH lesions and 76 presented HPV-13 upon PCR analysis. In the middle-income school, of the 144 subjects studied, 3 had FEH lesions and 8 presented HPV-13 upon PCR analysis. In the high-income elementary school, 96 students were studied, and none presented FEH lesions, however, 6 had HPV-13 positivity.

FEH and HPV-13 prevalence were inversely proportional to socioeconomic status. Lacking an association to a particular gender or difference in the age groups studied.

Keywords: Focal epithelial hyperplasia; Papillomavirus; Heck’s disease; HPV-13

Citation: Zavala-Garcia A, Briceño-Mena R, Romero-Beltran L, Kelly GAF, Ceron-Espinosa J, et al. (2017) Focal Epithelial Hyperplasia Prevalence in an Endemic Population, Molecular Association of HPV-13 to Asymptomatic Patients and Comparison Between Three Elementary Schools of Different Income Levels. J Immuno Biol 2:133. Doi: 10.4172/2476-1966.1000133

Copyright: ©2017 Zavala-García A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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