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Follicular Lymphoid Hyperplasia in Palate: A Case Report with Immunohistochemical Analysis and Review | OMICS International | Abstract
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Follicular Lymphoid Hyperplasia in Palate: A Case Report with Immunohistochemical Analysis and Review

Manuel Antonio Gordón-Núñez1*, Onilson Da Rocha Méndes Jr2, Leonardo Miguel Madeira Silva3 and Hébel Cavalcanti Galvão4
1Visiting professor, Dentistry department, Post-Graduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal / RN, Brazil
2DDS in Oral and Maxillofacial Surgery, Janduhy Carneiro Hospital, Patos /PB, Brazil
3Student of scientific initiation, discipline of oral pathology, Dentistry department, Rio grande do norte federal university – UFRN, Natal/RN, Brazil
4Associate professor, Dentistry department, Post-Graduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal / RN, Brazil
Corresponding Author : Manuel Antonio Gordón-Núñez
Dentistry department, Post-Graduate Program in Oral Pathology
Federal University of Rio Grande do Norte
Avenida Senador Salgado Filho, 1787, Lagoa Nova
CEP: 59056-000, Natal, Brazil
Tel/Fax: (55)(84) 3215-4138
E-mail: [email protected]
Received March 24, 2012; Accepted April 28, 2012; Published May 15, 2012
Citation: Gordón-Núñez MA, Da Rocha Méndes Jr O, Madeira Silva LM, Galvão HC (2012) Follicular Lymphoid Hyperplasia in Palate: A Case Report with Immunohistochemical Analysis and Review. J Clin Case Rep 2:148. doi:10.4172/2165-7920.1000148
Copyright: © 2012 Gordón-Núñez MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Follicular lymphoid hyperplasia of the hard palate is a reactive lymphoid proliferation which closely simulates the palatal lymphomas, both clinically and histologically. It is therefore imperative that the pathologist be familiar with the features that separate these two conditions. It reported a case of FLH in a 70-year-old white woman, showing a nodular lesion in right posterior soft palate, reddish, soft, asymptomatic. Histopathological analysis revealed lymphoid aggregates with discrete lobular appearance in the lamina propria of connective tissue showing numerous lymphocytes in the periphery with scanty cytoplasm and homogeneously basophilic nuclei and central areas of germinal centers
showing tingible-body macrophages and occasional mitotic figures. In order to distinguish Follicular Lymphoma (FL) from Follicular Hyperplasia (FH), immunohistochemical staining method for bcl-2 was used showing positivity in the mantle zone and absence of immunostaining in the cellular elements within the follicle centres.

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