Follicular Stem Cells in Androgenetic AlopeciaHend Gamil, Magda Assaf, Manal Elsayed, Khaled Gharib*, Ayman Yosef, Mohamed Khater, Mohamed Nasr and Mohamed Soliman
Department of Dermatology and Pathology, Faculty of Medicine, Zagazig University, Egypt
- *Corresponding Author:
- Khaled Gharib
Department of Dermatology and Pathology
Faculty of Medicine, Zagazig University, Egypt
E-mail: [email protected]
Received date: March 30, 2015; Accepted date: April 27, 2015; Published date: April 29, 2015
Citation: Gamil H, Assaf M, Elsayed M, Gharib K, Yosef A, et al. (2015) Follicular Stem Cells in Androgenetic AlopeciaJ Cytol Histol 6:324. doi:10.4172/2157-7099.1000324
Copyright: © 2015 Gamil H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Although the pathogenesis of androgenetic alopecia (AGA) is poorly understood, recent studies suggest that compromising the integrity of the follicular bulge area and or sebaceous gland may play a role. This study was designed to evaluate the role of follicular bulge stem cells in AGA. Twenty patients with AGA (17 males and 3 females) with a mean age of 24.05 ± 1.6 were the subjects of this study. A 4 mm punch biopsy specimen was obtained from both occipital skin and frontal affected area of scalp of each patient and embedded in paraffin. Tissue sections were immunostained using the Cytokeratin 15(CK 15) Ab-1 mouse monoclonal antibody. Cytokeratin 15 immunoreactivity was observed both in the frontal and occipital skin biopsies in the follicular bulge region and outer root sheath in all 20 AGA patients (100%). This study suggests that follicular stem cells in the bulge region are not the target in AGA. Further studies using other stem cell markers are recommended to clarify the role of follicular stem cells in AGA pathogenesis.