Foodborne Botulism in Mashhad from 2003 to 2010
- *Corresponding Author:
- Reza Afshari
Associate Profesor of Clinical Toxicology
Pharmaceutical Research center
Medical Toxicology Research Center
Mashhad University of medical Science, Mashhad, Iran
Tel: 0098 511 852 5315
Fax: 0098 511 859 8973
E-mail: [email protected]
Received Date: September 14, 2011; Accepted Date: December 18, 2011; Published Date: December 22, 2011
Citation: Habibiyan Nejad Z, Afshari R (2011) Foodborne Botulism in Mashhad from 2003 to 2010. J Clinic Toxicol 1:115. doi: 10.4172/2161-0495.1000115
Copyright: © 2011 Habibiyan Nejad Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objectives: Foodborne botulism has been an uncommon disease in Iran. It induces symmetrical cranial nerve palsies followed by descending, symmetric flaccid paralysis of voluntary muscles, which may eventually lead to respiratory failure and death. This study aimed to investigate clinical and paraclinical findings, and long onset symptoms of botulism poisoning in Mashhad over an eight - year period.
Materials and methods: All selected files from hospital-referred botulism poisoned patients were investigated which were opted from Imam Reza (p) Mashhad University Hospital, Iran. Patients’ clinical and paraclinical findings were noticed. In order to find out the period of time that patients have been free from any symptoms after discharging, all selected patients were contacted in early 2011. Cases were divided into two groups, namely sporadic and epidemic (more than one), and their findings were compared.
Results: Overall, 45 patients were selected. Mean incidence of Botulism in Khorasan-Razavi was 9.8× 10 5 . Among them 49.9% was Male. Main clinical findings were difficult speech (92%), ptosis (91%), diplopia (67%), nausea (58%), general weakness (92%), dizziness (70%) and constipation (25%). Patients were cleared from all symptoms and signs after discharging in 8.3 (9.6, 0-39) weeks. In outbreaks, time elapsed from exposure; headache and dysphagia were significantly different from sporadic cases.
Conclusion: Food borne botulism is rare, but it happens more frequently in middle-income countries such as Iran. The result of this study could be used as a clinical guideline to diagnose botulism in this area.