alexa Forkhead Box Protein O1 is Linked to Anti-Inflammatory Probiotic Bacteria Acting through Nuclear Factor-κB Pathway | OMICS International | Abstract
ISSN: 1948-5948

Journal of Microbial & Biochemical Technology
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Research Article

Forkhead Box Protein O1 is Linked to Anti-Inflammatory Probiotic Bacteria Acting through Nuclear Factor-κB Pathway

Ana Paula Mulet1, Karen Perelmuter2, Mariela Bollati-Fogolin2, Martina Crispo1* and Gianfranco Grompone3*

1Transgenic and Experimental Animal Unit, Institut Pasteur de Montevideo, Uruguay

2Cell Biology Unit, Institut Pasteur de Montevideo, Uruguay

3Instituto Nacional de Investigación Agropecuaria, INIA, Gerencia de innovación y comunicación, Uruguay

*Corresponding Author:
Martina C
Transgenic and Experimental Animal Unit
Institut Pasteur de Montevideo, Uruguay
Tel: 59825220910
E-mail: [email protected]
Gianfranco G
Instituto Nacional de Investigación Agropecuaria
INIA, Gerencia de innovación y comunicación
Uruguay
E-mail: [email protected]
 

Received date: April 17, 2017; Accepted date: May 10, 2017; Published date: May 17, 2017

Citation: Mulet AP, Perelmuter K, Bollati-Fogolin M, Crispo M, Grompone G (2017) Forkhead Box Protein O1 is Linked to Anti-Inflammatory Probiotic Bacteria Acting through Nuclear Factor-Κb Pathway. J Microb Biochem Technol 9:074-081. doi:10.4172/1948-5948.1000347

Copyright: © 2017 Mulet AP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Probiotics are widely used to promote health benefits around the world. Nevertheless, the mechanisms whereby probiotics exert its beneficial effect on the host are not well elucidated yet. In an attempt to obtain relevant insights on probiotics mechanisms of action, we studied the probiotic response via Nuclear factor-κB (NF-κB) and Forkhead box protein O1 (FoxO1), two transcription factors that were previously related with probiotic effects. We performed in vitro analysis to activate these transcription factors with Tumor Necrosis Factor alpha (TNFα) and Hydrogen Peroxide (H2O2) stimuli using a set of probiotic strains co-cultured with HT-29 cells. We found three strains, LrBPL8, LcA1 and LaBPL71 capable to reducing the NF-κB activation pathway in an inflammatory context. We also found that LcA1 reduced FoxO1 activation while another strain, IPM C+, increased it after the hydrogen peroxide treatment under the same conditions. Moreover, we described a complex relationship between FoxO1 downstream gene expression and these anti-inflammatory strains. Our results show that more than one pathway could be targeting NF-κB modulation, indicating the complexity of the probiotics’ mechanisms of action. The in vitro data presented here may help to design multi-strain probiotics mix that take advantage of the complementary and synergistic effects that they may induce in the host.

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