alexa Formulation and Development of Taste Masked Orally Disintegrating Tablets of Perindopril Erbumine by Direct Compression Method
ISSN : 2153-2435

Pharmaceutica Analytica Acta
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Research Article

Formulation and Development of Taste Masked Orally Disintegrating Tablets of Perindopril Erbumine by Direct Compression Method

Mukesh P Ratnaparkhi*

Marathwada Mitra Mandal’s College of Pharmacy, Thergaon, Pune-411033, India

*Corresponding Author:
Mukesh P. Ratnaparkhi
Marathwada Mitra Mandal’s College of Pharmacy
Thergaon, Pune-411033, India
E-mail: [email protected]

Received Date: June 20, 2012; Accepted Date: July 18, 2012; Published Date: July 22, 2012

Citation: Ratnaparkhi MP (2012) Formulation and Development of Taste Masked Orally Disintegrating Tablets of Perindopril Erbumine by Direct Compression Method. Pharmaceut Anal Acta 3:162. doi: 10.4172/2153-2435.1000162

Copyright: © 2012 Ratnaparkhi MP. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The aim of current study was to formulate and evaluate taste masked orally disintegrating tablets of Perindopril Erbumine. Taste masking was done by using Eudragit E 100 in the ratio of 1:3 (drug:polymer) by mass extrusion method. The preliminary batches were prepared by using different superdisintegrants like Ac-Di-Sol, Primogel, Tulsion-335 and Tulsion-339. From the preliminary study it was found that orodispersible tablets containing Ac-Di- Sol showed better disintegration time and it was considered for further studies. A 32 full factorial design was applied to optimize the formulations, nine batches were prepared and evaluated. It was observed from the evaluations that the batch A2 showed the best disintegration time and also completes drug release within five minutes. Hence it was concluded that orally disintegrating tablets of Perindopril Erbumine can be successfully formulated using Ac-Di-Sol.

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