alexa Formulation and Evaluation of Fast Dissolving Oral Films of Diazepam
ISSN: 2329-6887

Journal of Pharmacovigilance
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Research Article

Formulation and Evaluation of Fast Dissolving Oral Films of Diazepam

Ali MS, Vijendar C, Sudheer Kumar D and Krishnaveni J*

Department of Pharmaceutics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506 009, Telangana, India

*Corresponding Author:
Krishnaveni J
Department of Pharmaceutics
University College of Pharmaceutical Sciences
Kakatiya University, Warangal 506009, Telangana, India
Tel: 9701142628
E-mail: [email protected]

Received Date: March 22, 2016; Accepted Date: May 23, 2016; Published Date: May 28, 2016

Citation: Ali MS, Vijendar C, Kumar SD, Krishnaveni J (2016) Formulation and Evaluation of Fast Dissolving Oral Films of Diazepam. J Pharmacovigilance 4:210. doi: 10.4172/2329-6887.1000210

Copyright: © 2016 Ali MS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Oral films dissolve rapidly along with drug in mouth and majority of the drug is absorbed through buccal/oral mucosa in to systemic circulation avoiding first pass metabolism. The aim of present investigation was to formulate the Fast dissolving oral films (FDOF) of Diazepam an anti epileptic drug which is normally administered by intramuscular route or as rectal suppository in acute conditions of seizure emergencies. Oral films were prepared by solvent casting method using HPMC E3, E5, and E15 as a film formers and propylene glycol, PEG 400 as plasticizers and evaluated for mechanical properties, disintegration and in vitro dissolution. All formulations showed good mechanical properties and in vitro drug release. The optimized (F4A) Formulation (HPMC E5 and PEG 400) Exhibited drug release of 99.89% in 15 minutes which was significantly high when compared to marketed tablet valium (68.81%).

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