Formulation and Evaluation of Solasodine Transdermal Patches For Anti-Inflammatory Activity
The objective of the current study is to increase the efficacy and to improve the patience compliance of the herbal medicine which can be achieved by developing alternative drug delivery system. Transdermal drug delivery system has become proven technology which delivers the drug in controlled and non-invasive manner. Presently available synthetic medicines for inflammation cause gastrointestinal irritation and reappearance of symptoms. There is a need for the development of better anti-inflammatory medicine. Solanum surettense grows as a wild plant in many parts of India, which is a main plant source for therapeutically active compound Solasodine. Solasodine is isolated from S.surattense and characterization of the compound is done using TLC, IR, NMR and MASS spectroscopy. Transdermal patches are formulated using isolated solasodine by solvent evaporation method with two different polymers (HPMC and Ethyl cellulose). The formulations were subjected to various evaluation parameters like weight variation, folding endurance, percentage moisture absorbance, percentage moisture loss and drug content. In vitro drug release studies were carried out using Franz diffusion cell. Formulation containing HPMC as skeletal material shows maximum drug release of 99.8 % at the end of 5 hours and it is selected for further investigations. In vivo studies for anti-inflammatory activity is performed by carrageen induced rat paw edema technique. Solasodine patches treated group shows 57.1 % inhibition compared with standard Indomethacine treated group which shows 52.3 % inhibition at the end of 4th hour.