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Research Article

Formulation and In Vitro Evaluation of Fast Dissolving Tablet Containing Sildenafil Citrate Nanocrystals

 
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Abstract

Sildenafil citrate is a pharmacological agent which has proven useful in treatment of erectile dysfunction, pulmonary arterial hypertension as well as high altitude motion sickness. Sildenafil citrate exhibits an absolute bioavaibality of about 40% and is reported to result in maximum observed plasma concentration of about 30-120 minutes following after oral administration. Sildenafil citrate exhibits low water solubility,namely 3.5mg/ml. This low water solubility with its high presystemic metabolism have contributed to its low oral bioavailability. Thus,there is a need to to improve the bioavailability of sildenafil citrate. Fast dissolving tablet of sildenafil citrate were prepared with a intention to gain pre gastric absorption that will eliminate the presystemic metabolism of drug. Attempts were also made to improve the acqueous solubility of the drug by forming its nanocrystals. The nanocrystals of sildenafil citrate were formed by nanoprecipitation technique and were evaluated for particle size and shape by scanning electron microscopy and were also subjected to DSC and FTIR analysis.This formed nanocrystals were further considered as API for the fast dissolving tablet. The formulated F3 formulation(fast dissolving tablet containing cross povidone as polymer and sildenafil citrate nanocrystals) shows rapid drug release within 2 minutes as compared to the tablet containing pure drug

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