Formulation and Pharmacokinetics of Vitamin E TPGS Melt Dispersion Granules: An Approach to Improve Oral Delivery of Flurbiprofen
- *Corresponding Author:
- Sateesh Kumar Vemula
Department of Pharmacy
College of Medical and Health Sciences
Post Box No: 395, Nekemte, Ethiopia
E-mail: [email protected]
Received Date: January 01, 2015; Accepted Date: January 22, 2016; Published Date: January 29, 2016
Citation: Mohd AB, Vemula SK (2016) Formulation and Pharmacokinetics of Vitamin E TPGS Melt Dispersion Granules: An Approach to Improve Oral Delivery of Flurbiprofen. J Bioequiv Availab 8:089-94. doi:10.4172/jbb.1000274
Copyright: © 2016 Mohd AB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Formulation of solid dispersions using BCS class II drugs is one of the fruitful technologies to improve the drug solubility and dissolution rate to improve the bioavailability, but suffers from poor flowability and stability. To overcome the above problems, present research was intended to prepare the solid dispersions using combination of melt dispersion and surface adsorption methods. In the present study flurbiprofen melt dispersion granules were prepared by incorporating vitamin E TPGS as the carrier material and lactose as an adsorbent to improve the dissolution rate and flowability. Melt dispersion granules were evaluated for angle of repose, solubility studies, differential scanning calorimetry, in vitro dissolution studies, stability studies and finally subjected to pharmacokinetic studies. From the differential scanning calorimetry studies, change in the drug peak in formulation revealed the change in drug crystallinity. F4 formulation showed not only good flowability but also complete drug release in 15 min when compared to other formulations and pure drug. From the pharmacokinetic evaluation, F4 formulation showed 1.38- fold higher bioavailability and 1.32-fold higher Cmax compared to plain flurbiprofen. Hence, the formulated vitamin E TPGS melt dispersion granules were able to improve the dissolution rate as well as the bioavailability of flurbiprofen.