alexa Fractal and Euclidean Geometrical Diagnosis of Cervix Cytology
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Fractal and Euclidean Geometrical Diagnosis of Cervix Cytology

Javier Rodríguez1*, Signed Prieto2, Catalina Correa3, Fernando Polo4 and Paula López5

1Insight Group Director, Investigador de la Fundación Universitaria Ciencias de la Salud. Research Center - Clínica del Country, Bogotá, Colombia

2Insight Group researcher. Fundación Universitaria Ciencias de la Salud. Research Center - Clínica del Country, Bogotá, Colombia

3Psychologist, Insight Group researcher. Fundación Universitaria de Ciencias de la Salud. Research Center - Clínica del Country, Bogotá, Colombia

4Pathologist, Pathology Group Director, Fundación Universitaria de Ciencias de la Salud, Bogotá, Colombia

5Department of Medicine, Fundación Universitaria de Ciencias de la Salud, Bogotá, Colombia

*Corresponding Author:
Javier Rodríguez Velásquez
Cra. 79B No. 51-16 Sur.
Int. 5. Apartment. 102, Kennedy
Bogotá D.C., Colombia
Tel: 057 3134057252
E-mail: [email protected]

Received date: January 06, 2014; Accepted date: February 26, 2014; Published date: February 28, 2014

Citation: Rodríguez J, Prieto S, Correa C, Polo F, López P (2014) Fractal and Euclidean Geometrical Diagnosis of Cervix Cytology. J Cancer Sci Ther 6:081-086. doi:10.4172/1948-5956.1000253

Copyright: © 2014 Rodríguez J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Conventional methods for evaluation of cervix cytology show reproducibility problems. To solve this, there was developed a diagnostic methodology based on fractal and euclidean geometry, mathematically differentiating normality, L SIL and H SIL.
Objective: The aim of the present work is to confirm the clinical applicability of such diagnostic in a blind study.
Methods: The clinic diagnosis of 15 normal cells, 15 ASCUS, 15 L SIL and 15 H SIL was masked. Cellular nucleus and cytoplasm were evaluated calculating fractal dimension, number of spaces occupied by the frontier and number of pixels occupied by the surface of each object. The mathematical diagnosis was established and compared with the conventional diagnosis, calculating specificity, sensibility, negative likelihood ratio and Kappa coefficient.
Results: It was found that simultaneous measures of the nuclear surface and the subtraction between the frontiers of cytoplasm and nucleus, lead to differentiate normality, L SIL and H SIL. Both sensibility and specificity values were of 100 percent. Kappa coefficient was 1 and negative likelihood ratio was zero. 4 ASCUS showed mathematical measures of normality, while the remaining 11 showed values of L-SIL cells.
Conclusion: The mathematical diagnostic prove to be useful for clinical evaluation of cervix cytology, differentiating normality, L SIL and H SIL, quantifying how close it is the cell to a higher severity stage, and clearing up the undetermination of the ASCUS cells.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version