alexa Fragility of Cimetidine Drug Probed by Broadband Dielectric Spectroscopy | OMICS International | Abstract
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Case Report

Fragility of Cimetidine Drug Probed by Broadband Dielectric Spectroscopy

Sailaja U1* and Shahin Thayyil M2

1Department of Physics, M E S Keveeyam College, Valanchery, Malappuram, Kerala, India

2Department of Physics, University of Calicut, Kerala, India

*Corresponding Author:
Sailaja U
Department of Physics
M E S Keveeyam College
Valanchery, 676 552
Malappuram, Kerala, India
Tel: 0466-2240364
E-mail: [email protected]

Received Date: July 25, 2014; Accepted Date: September 29, 2014; Published Date: October 03, 2014

Citation: Sailaja U, Thayyil MS (2014) Fragility of Cimetidine Drug Probed by Broadband Dielectric Spectroscopy. Transcr Open Access 4:138. doi: 10.4172/2161-1025.1000138

Copyright: © 2013 Sailaja U, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Abstract

Cimetidine is a histamine H2-receptor antagonist that inhibits stomach acid production. It is largely used in the treatment of heartburn and peptic ulcers. One of the promising methods to improve the solubility and bioavailability of an active pharmaceutical ingredient is the amorphous phase which will have high free energy than that of the crystalline phase. The relaxation dynamics of cimetidine above the glass transition temperature has been studied by Broadband Dielectric Spectroscopy. Dielectric measurements of amorphous cimetidine were performed after its vitrification by fast cooling from few degrees above the melting point (412.50K). The relaxation processes observed above the glass transition temperature, were labeled as alpha and characterized. The temperature dependence of the structural relaxation time can be described over the entire measured range by single Vogel-Fulcher-Tamman (VFT) equation. From the VFT fits, the glass transition temperature was estimated as 316.27 K and a fragility or steepness index as 69, showing that cimetidine is an intermediate glass former.

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