alexa Free-Radical Processes in Stroke Patients with Vascular Comorbidity
ISSN: 0974-8369

Biology and Medicine
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Free-Radical Processes in Stroke Patients with Vascular Comorbidity

Ekaterina Vladimirovna Silina*, Aleksandra Sergeevna Orlova, Sofia Alekseevna Rumyantseva and Sergej Brankovich Bolevich

I.M. Sechenov First Moscow State Medical University (First MSMU), 8 Trubetskaya St., Moscow 119991, Russia

*Corresponding Author:
Silina EV
I.M. Sechenov First Moscow State
Medical University (First MSMU)
8 Trubetskaya St., Moscow 119991, Russia
E-mail: [email protected]

Received Date: July 01, 2016; Accepted Date: August 22, 2016; Published Date: August 29, 2016

Citation: Silina EV, Orlova AS, Rumyantseva SA, Bolevich SB (2016) Free-stroke Processes in Stroke Patients with Vascular Comorbidity. Biol Med (Aligarh) 8: 344. doi:10.4172/0974-8369.1000344

Copyright: © 2016 Silina et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Acute oxygen and glucose defi ciency during brain ischemia leads to the inability of neurons producing a suffi cient amount of adenosine triphosphate (ATP) using an oxidative metabolism. Energy defi ciency leads to neuronal death via different mechanisms including oxidative stress. This study aimed to evaluate the changes and main characteristics of free-radical processes in patients with acute stroke and transient ischemic attacks (TIA) in the presence of vascular comorbidity. One hundred forty-one patients with stroke (male—72, mean age—65.4813.44 years) and with a history of cardiovascular diseases (CVD). Free-radical formation was assessed in plasma based on oxidative (chemiluminescence intensity index—basal [CIIb] and zymosan-stimulated [CIIs]) and lipid-peroxidation markers (antiperoxide plasma activity [APA] and malondialdehyde [MDA]). During the follow-up period (from 6 to 72 months) the incidence of recurrent cardiovascular events, outcomes, and survival were assessed using a telephone interview. All patients who survived were rehospitalized and underwent neurologic assessment. A high level of vascular comorbidity was demonstrated. The level of imbalance of free-radical processes correlated with an acute-stroke severity with a maximal intensity of lipid peroxidation in hemorrhagic stroke and the activation of oxidative stage of free-radical processes in ischemic stroke. There was a signifi cant decrease of APA in both types of stroke, whereas TIA was characterized by maintenance of high APA levels (p  0.05). In patients with an acute-stroke free-radical imbalance increased proportional to the level of a vascular comorbidity. The decrease of APA level and increase of MDA level, which refl ect signifi cant oxidative imbalance and more extensive vascular damage, correlate with inferior recovery during the inpatient period (r 5 0.357; p  0.05 и r 5 0.234; p  0.001 respectively). It was demonstrated that low MDA and high APA level in patients with acute stroke are the prognostic markers of a good functional recovery during inpatient treatment and decreased strokeassociated mortality during long-term follow-up.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords