alexa Frequency of ABCG2 421C>A Genetic Variant and The Efficiency of Treatment with Rosuvastatin in Kazakh Male Patients
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Short Communication

Frequency of ABCG2 421C>A Genetic Variant and The Efficiency of Treatment with Rosuvastatin in Kazakh Male Patients

Kozhakhmetov SS1*, Kushugulova AR1, Kakimova AB1, Saduakhassova SA1, Urazova МS1, Khassenbekova ZHR1, Kozhakhmetova SS1, Beysembayeva SCH2, Sibagatova AS2, Tuleutayeva GK2, Urazbayeva GS2, Ongarbayeva AE2, Yakovenko GI2, Kissikova SL2 and Nurgozhin ТS1

1National Laboratory Astana, Center for Life Sciences, Nazarbayev University, Astana, Kazakhstan

2Medical Center Hospital of the President’s Affairs Administration of the Republic of Kazakhstan, Astana, Kazakhstan

*Corresponding Author:
Kozhakhmetov SS
National Laboratory Astana, Center for Life Sciences, Nazarbayev University, Astana, Kazakhstan
Tel: 7172706521
E-mail: [email protected]

Received date: August 02, 2016; Accepted date: September 16, 2016; Published date: September 19, 2016

Citation: Kozhakhmetov SS, Kushugulova AR, Kakimova AB, Saduakhassova SA, Urazova MS, et al. (2016) Frequency of ABCG2 421C>A Genetic Variant and The Efficiency of Treatment with Rosuvastatin in Kazakh Male Patients. J Mol Genet Med 10:225 doi:10.4172/1747-0862.1000225

Copyright: © 2016 Kozhakhmetov SS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

Rosuvastatin is one of the most effective lipid-lowering drugs. Nevertheless its activity varies in different populations. Important role in this belongs to ABCG2. The objective of this study was to determine the impact of ABCG2 genotype on therapeutic effect of rosuvastatin in Kazakh population. This study included 82 Kazakh patients with metabolic disorder undergoing 10 -20 mg/day of rosuvastatin therapy for 12 weeks. Our findings indicated that people with 421AA genotype had higher response to the drug. The frequency of minor alleles in the studied group was 29.5%.

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