alexa Frequency of Anti-HBc and HBV DNA detection in blood donors of Kerman province, Iran | OMICS International | Abstract
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
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Research Article

Frequency of Anti-HBc & HBV DNA detection in blood donors of Kerman province, Iran

Maryam Delavari1*, Naser Shahabi-Nejad2, Andre M.N. Renzaho1, Mohamad Javad Zahedi3 and Amin Reza Owhadi3

1Public Health Research, Evaluation and Policy cluster, Faculty of Health, Medicine, Nursing and Behavioural Sciences, Deakin University, Australia

2Research Centre for Tropical and Infectious Diseases, Kerman University of Medical Sciences, P.O. Box 76169-14133, Kerman, Iran

3University of Medical sciences, Kerman, Iran

*Corresponding Author:
Dr. Maryam Delavari
Public Health Research
Evaluation and Policy cluster Faculty of Health, Medicine
Nursing and Behavioural Sciences Deakin University 221 Burwood Highway Burwood 3125 Australia
Tel: +61 9 244 6036, +61 4 035 42500
E-mail: [email protected]

Received date: January 18, 2011; Accepted date: April 02, 2011; Published date: April 04, 2011

Citation: Delavari M, Shahabinejhad N, Renzaho A, Zahedi M, Owhadi AR (2011) Frequency of Anti-HBc & HBV DNA detection in blood donors of Kerman province, Iran. J Blood Disord Transfus 2:105. doi: 10.4172/2155-9864.1000105

Copyright: © 2011 Delavari M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Hepatitis B is a serious global infection disease and a major cause of mortality and morbidity worldwide. However, data on Occult Hepatitis B in Iran are scare. The current study assessed the frequency of Anti-HBc and HBV DNA in serum sample of healthy blood donors negative for HBsAg stratified by sex and age; and also investigated the relationship between detection of HBV-DNA and anti-HBc positivity. Since anti-HBc screening is not performed in Iranian Blood Bank, we assessed whether anti-HBc could be adopted as a screening assay for the donated blood. The study included a total of 1525 blood samples of blood donors negative for hepatitis B virus surface antigen ( 87% male with a mean age ± SD: of 31±8yr; and 13% female with a mean age ± SD of 30±6yr). Eight percent (121 out of 1525) of the blood samples with negative HBs-Ag were positive for Anti-HBc and were all from males. HBV-DNA was detected in 36 out of 121 anti-HBc+ specimens (29.7%). The study found a positive relation between anti-HBc positivity and detection of HBV-DNA in serum samples of HBs-Ag negative blood donors. Findings from this study suggest that, introducing anti HBc screening in Iran maybe very practical in order to limit the transmission risk of Occult Hepatitis B virus through blood transfusion.

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