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Frequency of Screening and SBT Technique Trial | OMICS International | Abstract
ISSN: 2167-0870

Journal of Clinical Trials
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Frequency of Screening and SBT Technique Trial

Burns KEA1,2,3*, Leena Rizvi2, Peter Dodek4,5, Francois Lamontagne6, Seely AJE7, Bram Rochwerg8,9, Maged Tanios10, Tom Piraino9,11, Cook DJ9,11, Eric Honig12, Robert Cirone13 and Canadian Critical Care Trials Group

1Interdepartmental Division of Critical Care, University of Toronto, Toronto, Canada

2Division of Critical Care Medicine, St Michael's Hospital, Toronto, Canada

3Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Canada

4Centre for Health Evaluation and Outcome Sciences and Division of Critical Care Medicine, St Paul’s Hospital, Vancouver, Canada

5University of British Columbia, Vancouver, Canada

6Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Canada

7Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada

8Juravinki Centre, Hamilton, Canada

9Department of Clinical Epidemiology and Biostatistics and Anesthesia, McMaster University, Hamilton, Canada

10Critical Care Medicine, Longbeach Memorial, Longbeach, California, USA

11St Joseph’s Hospital, Hamilton, Canada

12Critical Care Medicine, Emory University, Atlanta, USA

13St. Joseph’s Hospital, Toronto, Canada

*Corresponding Author:
Burns KEA
Clinician Scientist, Department of Medicine
Division of Critical Care
St. Michael’s Hospital and the Li Ka Shing Knowledge Institute, Ontario, Canada
Tel: 416-864-6060 X3567
Fax: 416-864-5210
E-mail: [email protected]

Received Date: Sep 15, 2016; Accepted Date: October 18, 2016; Published Date: Oct 28, 2016

Citation: Burns KEA, Rizvi L, Dodek P, Lamontagne F, Seely AJE, et al. (2016) Frequency of Screening and SBT Technique Trial. J Clin Trials 6:284. doi:10.4172/2167-0870.1000284

Copyright: © 2016 Burns KEA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Rationale: Research supports the use of screening protocols to identify patients who are candidates for weaning from mechanical ventilation, and the use of spontaneous breathing trials (SBTs) to predict ability to breathe spontaneously. However, once daily screening is poorly aligned with 24-hour continuous care in the intensive care unit (ICU) environment and the most effective SBT technique is not known. The optimal strategy to liberate our sickest patients from ventilators remains to be determined. Objectives: To assess our ability to recruit critically ill adults and adhere to the screening and SBT protocols. Methods: We propose a pilot, factorial design, randomized trial comparing once-daily versus at least twice daily screening and pressure support (PS) ± positive end-expiratory pressure (PEEP) (inspiratory ± expiratory support) or T-piece (no support) as the SBT technique in critically ill adults who are invasively ventilated for at least 24 hours in 11 North American ICUs. Respiratory Therapists (RTs) will screen all enrolled patients between 06:00 and 08:00 hours daily to identify SBT candidates. Patients in the at least twice daily screening arms will also be screened between 13:00 and 15:00 hours; additional screening will be permitted at clinician’s discretion. Once a screening assessment is passed, an SBT will be conducted with the assigned technique. Outcomes: The study will be considered feasible if at least 1 to 2 patients per ICU per month are recruited and if the screening and SBT protocols are adhered to >80% of the time. Relevance: The availability of RTs in ICUs presents an important opportunity to screen patients more frequently, conduct more frequent SBTs, and reduce the duration of invasive ventilation and ICU stay. FAST Trial Registration: Clinical NCT02399267.


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