alexa Fresh Red Blood Transfusion as a Successful Erythrocyte
ISSN: 2161-0495

Journal of Clinical Toxicology
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Research Article

Fresh Red Blood Transfusion as a Successful Erythrocyte Cholinesterase Supplement in Organophosphate Poisoning

Ying Wang1,2, Zhi-hui Huang2,3, Bin-yu Chen1,2# and Xiang-min Tong1,2#*

1Research Center of Blood Transfusion Medicine, Key Laboratory of Laboratory Medicine (Wenzhou Medical University), Ministry of Education, Zhejiang Provincial People's Hospital, Hangzhou, 310014, China

2Clinical Research Institute, Zhejiang Provincial People’s Hospital, Hangzhou, 310014, China

3School of Basic Medicine, Wenzhou Medical University, Wenzhou, 325035, China

#These authors contributed equally to this work.

*Corresponding Author:
Xiangmin Tong
Research Center of Blood Transfusion Medicine
Key Laboratory of Laboratory Medicine (Wenzhou Medical University)
Ministry of Education, Zhejiang Provincial People's Hospital
Hangzhou, 310014, China
E-mail: [email protected]

Received Date: May 24, 2016; Accepted Date: July 18, 2016; Published Date: July 25, 2016

Citation: Wang Y, Huang Z, Chen B, Tong X (2016) Fresh Red Blood Transfusion as a Successful Erythrocyte Cholinesterase Supplement in Organophosphate Poisoning. J Clin Toxicol 6:312. doi: 10.4172/2161-0495.1000312

Copyright: © 2016 Wang Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Despite improvements to standard treatments (atropine, oxime) and intensive care management, the mortality associated with organophosphate (OP) poisoning has not substantially decreased. In this study, we evaluated the role of packed red blood cells (RBCs) transfusion in acute OP poisoning. Patients diagnosed with OP poisoning were included in this prospective study, and then were transfused with packed RBCs stored less than 10 days or 10 to 35 days. Cholinesterase (ChE) level in blood, atropine usage and durations were recorded. We found both shorter- and longer-storage RBCs (200~400 ml) significantly increased AChE level in blood, improved ChE recovery, and reduced the usage and shortened the duration of atropine and followed clinical recovery. Shorter-storage RBCs had better effect than longer-storage (longer storage) ones. Due to erythrocyte cholinesterase supplement, packed RBCs might be used as an alternative approach in patients with OP poisoning, especially at the early stages.

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