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From 2D Cell Phenotypes to 3D Live High-content Imaging: New Ways to Windows | OMICS International | Abstract
ISSN: 2157-7099

Journal of Cytology & Histology
Open Access

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From 2D Cell Phenotypes to 3D Live High-content Imaging: New Ways to Windows

Kubatiev AA1,2, Zurina IM1*, Kosheleva NV1,3, Gorkun AA1, Saburina IN1,2 and Repin VS1,2

1FSBSI, Institute of General Pathology and Pathophysiology, 8, Baltiyskaya st., 125315, Moscow, Russia

2Russian Medical Academy of Postgraduate Education, 2/1, Barrikadnaya st., 123995, Moscow, Russia

3Faculty of Biology, Lomonosov Moscow State University, Moscow, Russian Federation

*Corresponding Author:
Zurina IM
FSBSI, Institute of General Pathology and Pathophysiology
8, Baltiyskaya st., 125315, Moscow, Russia
Tel: 79165220431
E-mail: [email protected]

Received Date: September 24, 2015 Accepted Date: October 15, 2015 Published Date: October 17, 2015

Citation:Kubatiev AA, Zurina IM, Kosheleva NV, Gorkun AA, Saburina IN, et al. (2015) From 2D Cell Phenotypes to 3D Live High-content Imaging: New Ways to Windows. J Cytol Histol 6:378. doi:10.4172/2157-7099.1000378

Copyright: ©2015 Kubatiev AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Abstract

Researches in the field of cellular and molecular mechanisms of cell variability, based on phenotypic interactions, remain one of the most central and promising problems in modern biology. The current paper proposes a possible model for studying "variability windows" and cell phenotype reprogramming using different somatic cell types (epithelial and mesenchymal cells) as well as different cell culture systems - 2D monolayer, 3D single spheroids and microtissues accompanied with up-to-date live time-lapse microscopy analysis.

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