alexa From Molecule Studies of Allergens to Development of Im
ISSN: 2155-6121

Journal of Allergy & Therapy
Open Access

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Review Article

From Molecule Studies of Allergens to Development of Immunotherapy of Allergies

Christine YY Wai1, Nicki YH Leung1, Ka Hou Chu1 and Patrick SC Leung2*

1School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

2Division of Rheumatology/Allergy, School of Medicine, University of California, Davis, CA 95616, USA

*Corresponding Author:
Patrick SC Leung
Division of Rheumatology/Allergy
School of Medicine
University of California
Davis, CA 95616, USA
Tel: 530-754- 4943
Fax: 530-754-4943
E-mail: [email protected]

Received date: October 30, 2012; Accepted date: November 26, 2012; Published date: November 30, 2012

Citation: Wai CYY, Leung NYH, Chu KH, Leung PSC (2012) From Molecular Studies of Allergens to Development of Immunotherapy of Allergies. J Aller Ther 3:124. doi: 10.4172/2155-6121.1000124

Copyright: © 2012 Wai CYY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Allergies are hypersensitive reactions that affect over 25% of the world population. Extensive studies have been directed to define patho-immunological mechanisms of allergy and the molecular characteristics of allergens. The emerging B cell and T cell epitope database has greatly facilitated the development of epitope-based immunotherapy that aims at modulating patients’ immune responses towards a specific allergen. Modifications on the B cell epitopes reduce the affinity of allergens towards IgE while inducing immuno-tolerance as in traditional therapies utilizing native allergens. T cell epitope-based immunotherapy is considered as a safe form of therapy since the small peptide fragments cannot form cross-links with IgE. In this review, current strategies in mapping B cell and T cell epitopes are discussed. Furthermore, current progress in the translation of epitope into potential immunotherapies is illustrated with specific examples on airway and food allergies.

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