alexa From Research Subgroup to Clinical Syndrome: Modifying
ISSN: 2161-0665

Pediatrics & Therapeutics
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Research Article

From Research Subgroup to Clinical Syndrome: Modifying the PANDAS Criteria to Describe PANS (Pediatric Acute-onset Neuropsychiatric Syndrome)

Susan E. Swedo1*, James F. Leckman2 and Noel R. Rose3

1Pediatrics & Developmental Neuroscience Branch, National Institute of Mental Health, National Institutes of Health, Bethesda MD, USA

2Child Study Center, Yale University, New Haven CT, USA

3Center for Autoimmune Disease Research, Johns Hopkins School of Medicine, Baltimore MD, USA

*Corresponding Author:
Susan E. Swedo
Pediatrics & Developmental Neuroscience Branch
ational Institute of Mental Health
National Institutes of Health, Bethesda MD, USA
E-mail: [email protected]

Received Date: December 06, 2011; Accepted Date: January 30, 2012; Published Date: February 02, 2012

Citation: Swedo SE, Leckman JF, Rose NR (2012) From Research Subgroup to Clinical Syndrome: Modifying the PANDAS Criteria to Describe PANS (Pediatric Acute-onset Neuropsychiatric Syndrome). Pediatr Therapeut 2:113. doi: 10.4172/2161-0665.1000113

Copyright: © 2012 Swedo SE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Despite continued debates about the role of Group A streptococcal infections in the etiopathogenesis of PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections), experts on both sides of the controversy agree that a subgroup of children with obsessive-compulsive disorder (OCD) have an unusually abrupt onset of symptoms, accompanied by a variety of comparably severe and acute neuropsychiatric symptoms. The acuity of symptom onset is the hallmark feature of their clinical presentation and the basis for the name proposed for an expanded clinical entity: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). Modifying the PANDAS criteria to eliminate etiologic factors and to clarify the initial clinical presentation produced three potential diagnostic criteria for PANS. These three criteria are discussed in detail. The article also proposes strategies for applying the PANS criteria in clinical settings and evaluating their validity and reliability through prospective research investigations.

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