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ISSN: 2153-0602

Journal of Data Mining in Genomics & Proteomics
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Research Article

From the Large Scale Expression Analysis of Lupus Nephritis to Targeted Molecular Medicine

Celine C Berthier1, Matthias Kretzler1 and Anne Davidson2*

1Department of Ophthalmology, Faculty of Medicine, Ankara University, Ankara, Turkey

2Department of Ophthalmology, Faculty of Medicine Ankara University, Turkey

*Corresponding Author:
Anne Davidson
Feinstein Institute for Medical Research
350 Community Drive Manhasset
NY 11030, USA
Tel: 516 562 3840
Fax: 516 562 2953
E-mail: [email protected]

Received date: December 01, 2011; Accepted date: March 25, 2012; Published date: March 27, 2012

Citation: Berthier CC, Kretzler M, Davidson A (2012) From the Large Scale Expression Analysis of Lupus Nephritis to Targeted Molecular Medicine. J Data Mining Genomics Proteomics 3:123. doi: 10.4172/2153-0602.1000123

Copyright: © 2012 Berthier CC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Current treatments for LN lack sufficient efficacy as they do not necessarily target the LN responsible pathways and therapeutic responses vary widely in the patient population. LN mouse models have been useful in delineating disease pathogenesis and for testing novel therapies, but they do not entirely represent the events happening in human LN. This review describes how recently developed systems biology technologies can help to integrate current knowledge with large scale experimental data to generate new hypotheses and insight into the regulatory events occurring in LN.

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