Fulminant Mycosis Fungoides with Tissue Eosinophilia: A Unique Presentation of Two Cases with Acro-Periorbital Ulceration and An Aggressive Clinical Course
David R Pearson*, Mayumi Fujita, and Whitney A High
University of Colorado School of Medicine in Aurora, USA
- *Corresponding Author:
- David R Pearson
University of Colorado Anschutz Medical Campus
1665 Aurora Ct, Mail Stop F703 Aurora
CO, 80045, USA
E-mail: [email protected]
Received Date: December 28, 2016 Accepted Date: February 26, 2017 Published Date: March 02, 2017
Citation: Pearson DR, Fujita M, High WA (2017) Fulminant Mycosis Fungoides with Tissue Eosinophilia: A Unique Presentation of Two Cases with Acro-Periorbital Ulceration and An Aggressive Clinical Course. J Mol Biomark Diagn 8: 337. doi: 10.4172/2155-9929.1000337
Copyright: © 2017 Pearson DR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We describe two unique cases of fulminant mycosis fungoides with remarkably similar and aggressive clinical courses resulting in death. Both cases demonstrated ulcerated palmar and periorbital plaques and marked tissue eosinophilia, which was confirmed by T-cell receptor γ chain gene rearrangement studies to display identical monoclonality at temporally and anatomically distinct sites. Dense eosinophilic infiltrates on biopsy led to misdiagnosis of inflammatory dermatoses in both instances.
While mycosis fungoides may be challenging to diagnose histologically, the presence of eosinophils in progressive disease may herald a poor prognosis and should not exclude the diagnosis.