alexa Functional Analysis of 3-Mercaptopyruvate Sulfurtransfe
ISSN: 2379-1764

Advanced Techniques in Biology & Medicine
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Functional Analysis of 3-Mercaptopyruvate Sulfurtransferase Using Knockout Mice

Yusuke Suwanai1,2, Noriyuki Nagahara1,2*, Zenya Naito1 and Hideo Orimo2
1Isotope Research Center, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
2Department of Metabolism and Nutrition, Graduate school of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
Corresponding Author : Noriyuki Nagahara
Isotope Research Center, Nippon Medical School
1-1-5 Sendagi Bunkyo-ku, Tokyo 113-8602, Japan
E-mail: [email protected]
Received: February 02, 2016;Accepted: February 11, 2016; Published: February 18, 2016
Citation: Suwanai Y, Nagahara N, Naito Z, Orimo H (2016) Functional Analysis of 3-Mercaptopyruvate Sulfurtransferase Using Knockout Mice. Adv Tech Biol Med 4:167. doi: 10.4172/2379-1764.1000167
Copyright: © 2016 Suwanai Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


3-mercaptopyruvate sulfurtransferase (MST) transfers sulfur from 3-mercaptopyruvate (3MP) or thiosulfate to a sulfur acceptor. We developed MST-knockout (MST-KO) mice to clarify the physiological role of MST. They showed increased anxiety-like behaviors. In the prefrontal cortex and hippocampus, levels of serotonin (5-hydroxytryptamin, 5-HT) and/or serotonin metabolite, 5-hydroxyindoleacetic acid were higher in MST-KO mice than in wild-type mice and further 5-HT2A receptor mRNA was increased. Experiments using MST-KO mouse revealed that MST produces hydrogen polysulfides from 3MP and sodium sulfide and hydrogen trisulfide was also enzymatically produced.


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