alexa Functional Analysis of 3-Mercaptopyruvate Sulfurtransfe
ISSN: 2379-1764

Advanced Techniques in Biology & Medicine
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Functional Analysis of 3-Mercaptopyruvate Sulfurtransferase Using Knockout Mice

Yusuke Suwanai1,2, Noriyuki Nagahara1,2*, Zenya Naito1 and Hideo Orimo2
1Isotope Research Center, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
2Department of Metabolism and Nutrition, Graduate school of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
Corresponding Author : Noriyuki Nagahara
Isotope Research Center, Nippon Medical School
1-1-5 Sendagi Bunkyo-ku, Tokyo 113-8602, Japan
E-mail: [email protected]
Received: February 02, 2016;Accepted: February 11, 2016; Published: February 18, 2016
Citation: Suwanai Y, Nagahara N, Naito Z, Orimo H (2016) Functional Analysis of 3-Mercaptopyruvate Sulfurtransferase Using Knockout Mice. Adv Tech Biol Med 4:167. doi: 10.4172/2379-1764.1000167
Copyright: © 2016 Suwanai Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

3-mercaptopyruvate sulfurtransferase (MST) transfers sulfur from 3-mercaptopyruvate (3MP) or thiosulfate to a sulfur acceptor. We developed MST-knockout (MST-KO) mice to clarify the physiological role of MST. They showed increased anxiety-like behaviors. In the prefrontal cortex and hippocampus, levels of serotonin (5-hydroxytryptamin, 5-HT) and/or serotonin metabolite, 5-hydroxyindoleacetic acid were higher in MST-KO mice than in wild-type mice and further 5-HT2A receptor mRNA was increased. Experiments using MST-KO mouse revealed that MST produces hydrogen polysulfides from 3MP and sodium sulfide and hydrogen trisulfide was also enzymatically produced.

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