alexa Functional and Morphological Thyroid Disorders in Hemod
ISSN: 2167-7948

Journal of Thyroid Disorders & Therapy
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Research Article

Functional and Morphological Thyroid Disorders in Hemodialysis Patients

Salama El Sayed Farag*
Nephrology Unit, Faculty of medicine, Department of Internal Medicine, Zagazig University, Egypt
Corresponding Author : Salama El Sayed Farag
Nephrology Unit, Faculty of Medicine
Department of Internal Medicine
Zagazig University, Zagazig, Egypt
E-mail: [email protected]
Received April 16, 2013; Accepted May 13, 2013; Published May 22, 2013
Citation: Sayed Farag SEl (2013) Functional and Morphological Thyroid Disorders in Hemodialysis Patients. Thyroid Disorders Ther 2:121. doi:10.4172/2167-7948.1000121
Copyright: © Sayed Farag SEl. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Abstract Background: Chronic kidney disease (CKD) results in complex endocrine and metabolism alterations including thyroid dysfunction. There is many mechanisms explained the link between thyroid and kidney disease, both of them affect each other, plus both consider as an independent factor for cardiovascular disease. Aims: We investigate the prevalence of morphological and functional discarder in CKD maintained on hemodialysis and it relation to dialysis duration. Study design and method: A cross section study included 60 CKD patient maintained on HD and 40 control subjects. All subject investigated with thyroid ultrasound and thyroid hormone screen including serum thyroxine (T4), Triiodothyronin (T3), Thyroid stimulating hormone (TSH), free T3, free T4, Thyroglobulin antibodies (TG Ab) and Thyroid peroxidase antibodies (TPO Ab). Results: HD patients had a higher prevalence of diffuse goiter than control subjects (26.7% versus 10%, p=0.045), we compared the prevalence of thyroid function disorders between the two group which showed significant high frequency of low T3 syndrome in HD group. The mean duration of hemodilaysis was not significantly correlated with mean thyroid volume and TSH level (r=-0.06, r=0.13) respectively. While there was positive correlation between TSH level and mean thyroid volume among HD patients (r=0.25 p<0.05). Conclusions: We concluded that CKD patients maintained on HD were associated with higher prevalent thyroid function and morphology disorders in compared with healthy subjects.

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