Functional Annotation of Conserved Hypothetical Proteins in Rickettsia Massiliae MTU5
- *Corresponding Author:
- Dr. Joy Hoskeri. H
P.G. Department of Studies and Research in
Biotechnology and Bioinformatics
Shankaraghatta – 577 451,
E-mail: [email protected]
Received Date: March 22, 2010; Accepted Date:April 11, 2010; Published Date: April 11, 2010
Citation: Hoskeri JH, Krishna V, Amruthavalli C (2010) Functional Annotation of Conserved Hypothetical Proteins in Rickettsia massiliae MTU5. J Comput Sci Syst Biol 3: 050-052. doi: 10.4172/jcsb.1000055
Copyright: © 2010 Hoskeri JH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Completed genome sequences are rapidly increasing for Rickettsia but most the genes in them does not have an assigned function. The present investigation mainly focused only on identifying the function of hypothetical proteins of Rickettsia massiliae MTU5 that were conserved in Rickettsia species. Nearly, 114 conserved hypothetical proteins were selected that were conserved in Rickettsia species. Function annotation was carried out by using databases like SMART, Interproscan, Pfam, JAFA, COG, and BLAST. Among 114 conserved hypothetical proteins only 35 proteins were annotated. The study motivated us to thoroughly study the genome of Rickettsia massiliae MTU5 by bioinformatics approach for categorizing the proteins whose function was unknown.