Journal of Cell Signaling
Open Access

Abstract

Functional Roles of Protein Arginine Methyltransferase 5 in Cardiovascular Diseases

Fang Yang, Wei Shu and Ming Chen

Protein arginine methyltransferase 5 (PRMT5) is a protein arginine methyl transferase that catalyzes the symmetrical dimethylation of arginine residues within target proteins. PRMT5 is shown to associate with and methylate histone or non-histone proteins in cells, and plays key roles in cell development, survival and apoptosis. In this review, the current state of knowledge and functional roles of PRMT5 in vascular systems are discussed.