Functional Roles of Protein Arginine Methyltransferase 5 in Cardiovascular DiseasesFang Yang1, Wei Shu2 and Ming Chen1,3*
- *Corresponding Author:
- Ming Chen
State Key Laboratory for the Chemistry and
Molecular Engineering of Medicinal Resources
School of Chemistry and Pharmacy
Guangxi Normal University
Guilin, 541004, P. R. China
E-mail: [email protected]
Received date: July 03, 2016; Accepted date: July 28, 2016; Published date: August 01, 2016
Citation: Yang F, Shu W, Chen M (2016) Functional Roles of Protein Arginine Methyltransferase 5 in Cardiovascular Diseases. J Cell Signal 1:123.
Copyright: © 2016 Yang F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Protein arginine methyltransferase 5 (PRMT5) is a protein arginine methyl transferase that catalyzes the symmetrical dimethylation of arginine residues within target proteins. PRMT5 is shown to associate with and methylate histone or non-histone proteins in cells, and plays key roles in cell development, survival and apoptosis. In this review, the current state of knowledge and functional roles of PRMT5 in vascular systems are discussed.