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ISSN: 2161-0398

Journal of Physical Chemistry & Biophysics
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Research Article

Functionalization of Ceramic Liposomal Nanoparticles, Cerasomes, with Antibodies

M.T. Stamm1, Z. Zha1,2, L. Jiang1, Z. Dai2 and Y. Zohar1*
1The University of Arizona, Tucson, Arizona, USA
2Harbin Institute of Technology, Harbin, China
Corresponding Author : Y. Zohar
The University of Arizona, Tucson, Arizona, USA
Tel: 15-20-62-68-093
E-mail: [email protected]
Received January 23, 2012; Accepted February 22, 2012; Published February 25, 2012
Citation: Stamm MT, Zha Z, Jiang L, Dai Z, Zohar Y (2012) Functionalization of Ceramic Liposomal Nanoparticles, Cerasomes, with Antibodies. J Physic Chem Biophysic 2:105. doi:10.4172/2161-0398.1000105
Copyright: © 2012 Stamm MT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Ceramic nanoparticles and silica microparticles are functionalized with antibodies on their surfaces that act as targeting ligands. For the ceramic liposomal nanoparticles, cerasomes, this is achieved by using the siloxane network present on the cerasome surface as the foundation for chemical treatment processes previously developed for silicon surfaces. The bio-functionality and physical integrity of the cerasomes are characterized, demonstrating successful immobilization of antibodies on the cerasome surface. The surface functionalization allows the cerasomes to deliver drugs to targeted cells expressing certain types of receptors with desired selectivity and specificity that are not possible using standard liposomes. The Silica microparticles are used to mimic cerasomes in experiments targeting cancer cells and the particle-cell specific binding due to the bio-functionalization process is demonstrated.

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