alexa Functionalized Nanoparticles for Drug Delivery, One- and Two-photon Photodynamic Therapy as a Promising Treatment of Retinoblastoma | OMICS International | Abstract
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
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Research Article

Functionalized Nanoparticles for Drug Delivery, One- and Two-photon Photodynamic Therapy as a Promising Treatment of Retinoblastoma

Audrey Gallud1, Afitz Da Silva1, Marie Maynadier1, Ilaria Basile1, Simon Fontanel1, Cyndie Lemaire1, Philippe Maillard2, Mireille Blanchard- Desce3, Olivier Mongin3, Alain Morère1, Jean-Olivier Durand4, Laurence Raehm4, Marcel Garcia1 and Magali Gary-Bobo1*
1Institut des Biomolécules Max Mousseron, CNRS UMR5247, Université de Montpellier 1, Université de Montpellier 2, Faculté de Pharmacie, 15 avenue Charles Flahault, 34093 Montpellier, France
2Institut Curie, Section de Recherches, Centre Universitaire, Université Paris-Sud, F-91405 Orsay, France
3Chimie et Photonique Moléculaires, CNRS UMR 6510, Campus de Beaulieu, Université Rennes 1, 35042 Rennes Cedex, France
4Institut Charles Gerhardt Montpellier, UMR 5253, CNRS-UM2-ENSCM-UM1, CC1701 Place Eugène Bataillon, 34095 Montpellier Cedex 05, France
Corresponding Author : Magali Gary-Bobo
Institut des Biomolécules Max Mousseron
CNRS UMR5247, Université de Montpellier 1
Université de Montpellier 2
Faculté de Pharmacie, 15 avenue Charles Flahault
34093 Montpellier, France
E-mail: [email protected]
Received June 14, 2013; Accepted July 17, 2013; Published July 23, 2013
Citation: Gallud A, Silva AD, Maynadier M, Basile I, Fontanel S, et al. (2013) Functionalized Nanoparticles for Drug Delivery, One- and Two-photon Photodynamic Therapy as a Promising Treatment of Retinoblastoma. J Clin Exp Ophthalmol 4:288. doi:10.4172/2155-9570.1000288
Copyright: © 2013 Gallud A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Retinoblastoma is a rare cancer triggered by genetic mutation that forms in the eyes of children. In industrialized countries, 95% of patients are cured by chemotherapy and conservative treatments. However these treatments can increase the risk of secondary tumors in patients with a constitutional alteration of the retinoblastoma gene Rb1. Photodynamic therapy (PDT) represents a therapeutic approach and may reduce the incidence of secondary tumors. PDT is an established cancer treatment based on the light activation of a photosensitizing agent thus generating cytotoxic reactive oxygen species that cause cellular damage. We focused on mesoporous silica nanoparticles (MSN) for one-photon excited PDT combined with drug delivery and carbohydrate targeting applied on retinoblastoma. We demonstrated that bitherapy (camptothecin delivery and PDT) performed with MSN was efficient in inducing retinoblastoma cell death. Alternatively, MSN designed for two-photon excited PDT were also studied and irradiation in near-infrared at low fluency efficiently killed retinoblastoma cancer cells. These data provide new evidences of the potential of functionalized and targeted MSN for treatment of retinoblastoma and could lead to propose a non-invasive therapy with reduced side effects.

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