Glucosylceramides from Pseudallescheria/Scedosporium Complex
Rollin-Pinheiro R, Meirelles JV, Bernardino MC and Barreto-Bergter E*
Department of General Microbiology, Institute of Microbiology Paulo de Goes, Brazil
- *Corresponding Author:
- Barreto-Bergter E
Department of General Microbiology
Institute of Microbiology Paulo de Goes
E-mail: [email protected]
Received date: December 14, 2016, 2016; Accepted date: January 18, 2017; Published date: January 23, 2017
Citation: Rollin-Pinheiro R, Meirelles JV, Bernardino MC, Barreto-Bergter E (2017) Fungal Hyphal Growth – Spitzenkörper versus Apical Vesicle Crescent. Fungal Genom Biol 7:147. doi:10.4172/2165-8056.1000147
Copyright: © 2017 Rollin-Pinheiro R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Pseudallescheria/Scedosporium species are filamentous fungi widely distributed in nature. Some are considered emerging pathogen due to its clinical importance, especially in immunocompromised patients. During the last few years, many virulence factors have been described, some of them being molecules localized on the fungal cell wall, such as glycoproteins, polysaccharides and glycolipids. In this context, one glycosphingolipid specifically, glucosylceramide (GlcCer), has been chemically identified and its biological roles have been described. GlcCer is a conserved structure in the Pseudallescheria/Scedosporium complex and also in other fungal species. In addition, it plays important roles in fungal growth and differentiation, host-pathogen interaction, immune response modulation and it has been considering a potential target for new antifungal drugs. The use of monoclonal antibodies has shown a possible synergism with current antifungal drugs use in the clinical settings. Therefore, the study of this class of lipids is promising in order to clarify the Pseudallescheria/Scedosporium growth, pathogenesis and fungal treatment.