alexa Galanin-like Peptide Ameliorates Obesity by Control of Food Intake and Energy Metabolism
ISSN : 2153-2435

Pharmaceutica Analytica Acta
Open Access

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Review Article

Galanin-like Peptide Ameliorates Obesity by Control of Food Intake and Energy Metabolism

Satoshi Hirako1, Fumiko Takenoya1,2, Haruaki Kageyama1,3, Nobuhiro Wada1, Mai Okabe4 and Seiji Shioda1*

1Department of Anatomy, Showa University School of Medicine, Tokyo, Japan

2Department of Exercise and Sports Physiology, Hoshi University School of Pharmacy and Pharmaceutical Science, Tokyo, Japan

3Faculty of Health Care, Kiryu University, Gunma, Japan

4Tokyo Shokuryo Dietitian Academy, Tokyo, Japan

*Corresponding Author:
Seiji Shioda
Department of Anatomy, Showa University School of Medicine
1-5-8 Hatanodai,Shinagawa-ku, Tokyo 142-8555, Japan
Tel: +81-3-3784-8104
Fax: +81-3-3784-8615
E-mail: [email protected]

Received date: April 17, 2014; Accepted date: May 27, 2014; Published date: May 30, 2014

Citation: Hirako S, Takenoya F, Kageyama H, Wada N, Okabe M, et al. (2014) Galanin-like Peptide Ameliorates Obesity by Control of Food Intake and Energy Metabolism. Pharm Anal Acta 5:297. doi: 10.4172/2153-2435.1000297

Copyright: © 2014 Hirako S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Galanin-like peptide (GALP) is a 60 amino acid neuropeptide that was first isolated from the porcine hypothalamus. It is produced in the hypothalamic arcuate nucleus by neurons that form networks with other neurons containing peptides involved in the control of feeding behavior. GALP plays an important role in the regulation of feeding, body weight and energy metabolism. Although the physiological actions of GALP are yet to be fully elucidated, it is possible, given the anti-obesity effect of GALP seen in relation to food intake and body weight loss in obese mice, that GALP could be applied clinically to combat obesity in humans. Here we summarize what is known about the regulation of energy metabolism by GALP, and describe results in animals that could possibly lead to the clinical use of GALP to treat obesity.

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