alexa Galectins in the Pathogenesis of Rheumatoid Arthritis
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Review Article

Galectins in the Pathogenesis of Rheumatoid Arthritis

Song Li1, Yangsheng Yu1, Christopher D Koehn2, Zhixin Zhang1,3 and Kaihong Su1,2,3*
1Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA
2Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
3The Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, NE 68198, USA
Corresponding Author : Kaihong Su, PhD
Associate Professor
Department of Pathology and Microbiology
University of Nebraska Medical Center
LTC 11724, 987660 Nebraska Medical Center
Omaha, NE 68198-7660, USA
Tel: 402-559-7612
Fax: 402-559-7716
E-mail: [email protected]
Received August 26, 2013; Accepted September 23, 2013; Published September 30, 2013
Citation: Li S, Yu Y, Koehn CD, Zhang Z, Su K (2013) Galectins in the Pathogenesis of Rheumatoid Arthritis. J Clin Cell Immunol 4:164. doi:10.4172/2155-9899.1000164
Copyright: © 2013 Li S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Rheumatoid arthritis (RA) is a complex and common systemic autoimmune disease characterized by synovial inflammation and hyperplasia. Multiple proteins, cells, and pathways have been identified to contribute to the pathogenesis of RA. Galectins are a group of lectins that bind to β-galactoside carbohydrates on the cell surface and in the extracellular matrix. They are expressed in a wide variety of tissues and organs with the highest expression in the immune system. Galectins are potent immune regulators and modulate a range of pathological processes, such as inflammation, autoimmunity, and cancer. Accumulated evidence shows that several family members of galectins play positive or negative roles in the disease development of RA, through their effects on T and B lymphocytes, myeloid lineage cells, and fibroblast-like synoviocytes. In this review, we will summarize the function of different galectins in immune modulation and their distinct roles in RA pathogenesis.

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