Gallic Acid: A Promising Lead Molecule for Drug Development
- *Corresponding Author:
- Syed Mohammed Basheeruddin Asdaq
College of Pharmacy, Al-Maarefa Colleges for Science and Technology, Riyadh, Saudi Arabia
E-mail: [email protected]
Received date: January 08, 2016; Accepted date: January 27, 2016; Published date: January 31, 2016
Citation: Nayeem N, Asdaq SMB, Salem H, AHEl-Alfqy S (2016) Gallic Acid: A Promising Lead Molecule for Drug Development. J App Pharm 8:213. doi: 10.4172/1920-4159.1000213
Copyright: © 2016 Nayeem N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Gallic acid and its congeners are commonly present in variety of fruits and number of plants. In addition to its natural origin, large number of synthesized gallic acid derivatives are also available. It has a wide range of industrial uses including its role as standard for determing phenolic content of analytes in pharmaceutical industry, as source material for ink, paints and colour developer. Studies on gallic acid and its derivatives have exhibited its potential for combating oxidative damages, cancer manifestations and microbial infestations. Further, gallic acid extracted from different natural sources has been implicated to possess potency to ameliorate neurodegenerative disorders and aging. Furthermore, large number of reseach explorations are available to show its ability for the treatment of diabetes, ischemic heart diseases, ulcer and other ailments. In this review, an attempt is made to compile the scattered information on gallic acid and its derivatives for their pharmacological role, isolation and extraction procedures as well as quantification. This might help our research fraternity to explore gallic acid in their future research as a lead compound for new drug development.