alexa Gallic Acid Attenuates Dimethylnitrosamine-induced Acute Liver Injury in Mice through Nrf2-mediated Induction of Heme Oxygenase-1 and Glutathione-s-transferase Alpha 3
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Gallic Acid Attenuates Dimethylnitrosamine-induced Acute Liver Injury in Mice through Nrf2-mediated Induction of Heme Oxygenase-1 and Glutathione-s-transferase Alpha 3

Shaohua Ma, Li Lv*, Qian Lu, Yubing Li, Feng Zhang, Musen Lin, Dongyan Gao, Kexin Liu, Xiaofeng Tian and Jihong Yao*

Department of Pharmacology, Dalian Medical University, China

*Corresponding Author:
Li Lv
Department of Pharmacology
Dalian Medical University, China
Tel: +86411861102
E-mail: [email protected]

Jihong Yao
Department of Pharmacology
Dalian Medical University, China
Tel: +86411861102
E-mail: [email protected]

Received date: July 25, 2014; Accepted date: August 20, 2014; Published date: August 22, 2014

Citation: Ma S, Lv L, Lu Q, Li Y, Zhang F, et al. (2014) Gallic Acid Attenuates Dimethylnitrosamine-induced Acute Liver Injury in Mice through Nrf2-mediated Induction of Heme Oxygenase-1 and Glutathione-s-transferase Alpha 3. Med chem 4:663-669. doi: 10.4172/2161-0444.1000208

Copyright: © 2014 Ma S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Gallic acid, a widely distributed phenolic acid present in various plant species, has been demonstrated to possess anti-inflammatory, antioxidant and anticarcinogenic properties. In this study, the protective effect of gallic acid on acute liver injury induced by dimethylnitrosamine in mice was investigated. We attempted to explore the molecular mechanism from a perspective of phase â…¡ enzymes, which plays a crucial role in cellular defense against oxidative stress. Toxicant caused severe hepatic pathological damage and significant increase of serum transaminase levels. Hepatic lipid peroxidation and the glutathione depletion could also be observed after dimethylnitrosamine administration. Pretreatment of gallic acid at different doses could inhibit hepatic submassive necrosis and attenuate all the marker parameters in both serum and liver tissue. Administration of gallic acid was found to increase the expression level of heme oxygenase-1 (HO-1) and glutathione-s- transferase alpha 3 (GSTA3), thereby enhance the detoxication ability in liver tissue. The upregulation of phase â…¡ enzymes is caused, at least in part, by the nuclear accumulation of Nrf2, a transcriptional factor which binds to the antioxidant response element of DNA and triggers the expression of phase â…¡ enzymes. These findings provide further insight of hepatoprotection mediated by gallic acid.

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