alexa Gamma-delta T Cells may Function as Carrier Vehicles in Adenovirus Vector-based Gene Therapy | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Gamma-delta T Cells may Function as Carrier Vehicles in Adenovirus Vector-based Gene Therapy

Michio Naoe1*, Yoshio Ogawa1, Yuki Hasebe1, Kozo Fuji1, Sanju Iwamoto2, Hiroyuki Mizuguchi3, Takashi Aoi4, Shuji Terao5

1Department of Urology, Showa University, Tokyo, Japan

2Department of Biochemistry, Showa University, Tokyo, Japan

3Department of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Science, Osaka University, Osaka, Japan

4Division of iPS cell Applications, graduate School of Medicine, Kobe University, Hyogo, Japan

5Terao Clinic, Hyogo, Japan

*Corresponding Author:
Michio Naoe, M.D
Department of Urology, Showa University
1-5-8, Hatanodai, Shinagawa-ku, Tokyo, Japan
Tel: +81-3-3784-8560
Fax: +81-3-3784-1400
E-mail: [email protected]

Received Date: September 10, 2013; Accepted Date: November 05, 2013; Published Date: November 08, 2013

Citation: Naoe M, Ogawa Y, Hasebe Y, Fuji K, Iwamoto S, et al. (2013) Gammadelta T Cells may Function as Carrier Vehicles in Adenovirus Vector-based Gene Therapy. J Cancer Sci Ther 5:384-390. doi: 10.4172/1948-5956.1000230

Copyright: © 2013 Naoe M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Developing new treatments that reduce prostate cancer progression is important. Therapeutic efficacy of conventional gene therapy for metastatic prostate cancer is still low. Lower induction rate of naked genes into target cell is due to reduced expression of adenovirus receptor on cancer cell and also due to high seroprevalence of anti-Ad antibodies in adults. Therefore, efficient Ad carrier systems that circumvent these problems should be developed. Gamma-delta T cells have demonstrated high affinity to cancer cells. CD46, which leads to broad tropism in Ad35 vectors, is expressed in hematopoietic cells, including γδ T cells. In this study, we demonstrate the potential of γδ T cells as “vehicles” for transporting Ad5/F35 vectors and genes into cancer cells.

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7