Ganciclovir Loaded Chitosan Nanoparticles: Preparation and CharacterizationPatel R1, Gajra B1,2, Parikh RH1 and Gayatri Patel1*
- *Corresponding Author:
- Gayatri Patel
3600 Majormeckanzy drive
E-mail: [email protected]
Received Date: November 23, 2016 Accepted Date: December 22, 2016 Published Date: December 28, 2016
Citation: Patel R, Gajra B, Parikh RH, Patel G (2016) Ganciclovir Loaded Chitosan Nanoparticles: Preparation and Characterization. J Nanomed Nanotechnol 7: 411. doi: 10.4172/2157-7439.1000411
Copyright: © 2016 Patel R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Chitosan Nanoparticles (CSNPs), as drug carrier, can be utilized for enhancing permeability of poorly absorbed drugs. The aim of this work was to enhance the permeability of Ganciclovir (GCV) by loading into CSNPs. An ionic gelation method was undertaken to develop GCV loaded CSNPs. Several process and formulation parameters were screened and optimized through 25-2 fractional factorial design and Box-Behnken design respectively. The CSNPs were evaluated and characterized for their particle size and shape, surface charge, entrapment efficiency, crosslinking mechanism (dried CSNPs) and drug release study. The optimized CSNPs were found with particle size of 121.20 ± 2.7 and entrapment efficiency (%EE) of 85.15 ± 1.1%. Transmission electron microscopy, scanning electron microscopy and dynamic light scattering technique revealed spherical particles with uniform size. The in vitro release profile was found to be sustained up to 24 hr. Thus, incorporation of GCV into CSNPs results in enhanced permeability, that may in turn increase overall oral absorption of the drug.