alexa Ganciclovir Loaded Chitosan Nanoparticles: Preparation and Characterization
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

Ganciclovir Loaded Chitosan Nanoparticles: Preparation and Characterization

Patel R1, Gajra B1,2, Parikh RH1 and Gayatri Patel1*

1Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus, Changa – 388421, Anand, Gujarat, India

2Walmart Pharmacy, 3600 Majormeckanzy drive, Vaughan, Ontario, Canada

*Corresponding Author:
Gayatri Patel
Walmart Pharmacy
3600 Majormeckanzy drive
Vaughan, Ontario,Canada
Tel: 905-832-659
E-mail: [email protected]

Received Date: November 23, 2016 Accepted Date: December 22, 2016 Published Date: December 28, 2016

Citation: Patel R, Gajra B, Parikh RH, Patel G (2016) Ganciclovir Loaded Chitosan Nanoparticles: Preparation and Characterization. J Nanomed Nanotechnol 7: 411. doi: 10.4172/2157-7439.1000411

Copyright: © 2016 Patel R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Chitosan Nanoparticles (CSNPs), as drug carrier, can be utilized for enhancing permeability of poorly absorbed drugs. The aim of this work was to enhance the permeability of Ganciclovir (GCV) by loading into CSNPs. An ionic gelation method was undertaken to develop GCV loaded CSNPs. Several process and formulation parameters were screened and optimized through 25-2 fractional factorial design and Box-Behnken design respectively. The CSNPs were evaluated and characterized for their particle size and shape, surface charge, entrapment efficiency, crosslinking mechanism (dried CSNPs) and drug release study. The optimized CSNPs were found with particle size of 121.20 ± 2.7 and entrapment efficiency (%EE) of 85.15 ± 1.1%. Transmission electron microscopy, scanning electron microscopy and dynamic light scattering technique revealed spherical particles with uniform size. The in vitro release profile was found to be sustained up to 24 hr. Thus, incorporation of GCV into CSNPs results in enhanced permeability, that may in turn increase overall oral absorption of the drug.

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