Gastric Cancer Stem Cells and Resistance to Cancer TherapyMasakazu Yashiro1,2*
- *Corresponding Author:
- Masakazu Yashiro M.D
Department of Surgical Oncology
Osaka City University Graduate School of Medicine
1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan
Tel: (+81) 6-6645-3838
Fax: (+81) 6-6646-6450
E-mail: [email protected]
Received date: July 04, 2014; Accepted date: July 22, 2014; Published date: July 24, 2014
Citation: Yashiro M (2014) Gastric Cancer Stem Cells and Resistance to Cancer Therapy. Chemotherapy 3:135. doi:10.4172/2167-7700.1000135
Copyright: © 2014 Yashiro M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Gastric cancer remains a major global health threat, and most patients with advanced stage disease require chemotherapy. Resistance to therapy is a major obstacle in the management of gastric cancer, which may be due to cancer stem cells that are defined as “cancer cells within a tumor that possess the capacity for self-renewal and that can cause the heterogeneous lineage of cancer cells that constitute the tumor.” Gastric cancer stem cells exhibit characteristic biomarkers, signaling pathways, and crosstalk networks with tumor microenvironment. Targeting of these characteristics, which play important roles in cancer stem cells resistance, may provide new therapeutic modalities for gastric cancer.