Gastric Schwannoma, an Unusual Synchronous Tumor with Renal Cell CarcinomaChih-Yi Liu1 and Yih-Yiing Wu1,2*
- *Corresponding Author:
- Dr. Yih-Yiing Wu
No. 2, Lane 59, Jiancheng Road
Sijhih District, New Taipei City, Taiwan
Tel: +886-2-26482121 ext. 3740
E-mail: [email protected]
Received date: March 26, 2011; Accepted date: April 22, 2011; Published date: April 25, 2011
Citation: Liu CY, Wu YY (2011) Gastric Schwannoma, an Unusual Synchronous Tumor with Renal Cell Carcinoma. J Cytol Histol 2:119. doi:10.4172/2157-7099.1000119
Copyright: © 2011 Liu CY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Schwannomas, also called neurilemomas, are neurogenic tumors derived from Schwann cells of nerve sheath. They are relatively common in head, neck, extremities, retroperitoneum, posterior spinal roots and cerebellopontine angle, and are generally benign and slow-growing with rare recurrence or malignant transformation. However, they are rare in the gastrointestinal (GI) tract and mostly located in the stomach. Gastric schwannomas represent about 2% of the gastric mesenchymal neoplasms, and are clinically and grossly nearly indistinguishable from gastrointestinal stromal tumors (GISTs). GISTs are the major primary mesenchymal tumors of the GI tract. They have a variable malignant potential and can be coexistent with renal cell carcinomas (RCCs). In contrast, gastric schwannomas are regarded as benign and no concurrent malignancies have been documented. Here, we report a 54-year-old woman having a right radical nephrectomy for a clear cell RCC, and then received a radical subtotal gastrectomy for a gastric tumor under the impression of GIST four months later. Histopathologically, the gastric tumor was a submucosal spindle cell neoplasm with a particular peripheral lymphoid cuff. The neoplastic cells were immunohistochemically positive for S-100 protein, but negative for CD117 (c-kit), CD34, smooth muscle actin, desmin and Dog1. Eventually, the gastric submucosal tumor was confirmed to be a rare benign gastric schwannoma, which was an unusual synchronous tumor with RCC.