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Genes Encoding Enzymatic Activities Implicated in the Eicosanoid Cascade of Arachidonic Acid and their Receptors are Expressed at mRNA Levels in Human Meningiomas | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

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Research Article

Genes Encoding Enzymatic Activities Implicated in the Eicosanoid Cascade of Arachidonic Acid and their Receptors are Expressed at mRNA Levels in Human Meningiomas

Rafael De Armas1,3, Karine Durand1, Nicolas Weinbreck1, Sandrine Robert1, Jean-Jacques Moreau2, Matias Pebet3, François Labrousse1 and Yves Denizot4*

1Service d’Anatomie Pathologique, CHU Dupuytren, Limoges, France

2Service de Neurochirurgie, CHU Dupuytren, Limoges, France

3Hospital de Clinicas, Instituto de Neurologia, Montevideo, Uruguay

4UMR CNRS 6101, Centre National de la Recherche Scientifique, Université de Limoges, France

*Corresponding Author:
Dr. Yves Denizot
UMR CNRS 6101, Faculté de
Médecine, 2 rue Dr. Marcland, 87025 Limoges, France
Phone : (33) 5 55 43 58 96,
Fax: (33) 5 55 43 58 97,
E-mail : [email protected]

Received Date: February 01, 2010; Accepted Date: February 25, 2010; Published Date: February 25, 2010

Citation: De Armas R, Durand K, Weinbreck N, Robert S Jean-Jacques Moreau, et al. (2010) Genes Encoding Enzymatic Activities Implicated in the Eicosanoid Cascade of Arachidonic Acid and their Receptors are Expressed at mRNA Levels in Human Meningiomas. J Cancer Sci Ther 1:003-007. doi: 10.4172/1948-5956.1000015

Copyright: © 2009 De Armas R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In view of the important oncogenic action of lipoxygenase (LOX) and cycloxygenase (COX) enzymatic activities we investigated, by using real time PCR, their presence in human meningiomas. Results indicated the presence of 5-LOX, 12-LOX, 15-LOX1, 15-LOX2, COX-1, COX-2, prostaglandin E (PGE) synthase, prostacyclin (PGI) synthase and thromboxane (TX) synthase transcripts in meningiomas but without relation to the tumor grade, the subtype of meningiomas, the presence of inflammatory infiltrated cells, of an associated edema, mitosis, brain invasion, vascularisation or necrosis. Similar results were found for BLT1 and BLT2 transcripts (encoding LTB4 receptors) and for prostanoid receptor transcripts (EP1-4 for PGE2, IP for PGI2 and TP for TXA2). In conclusion, genes encoding enzymatic activities implicated in the eicosanoid cascade are expressed in meningiomas. LOX- and COX-derived arachidonic acid metabolites might act on tumor growth not only by acting on cell growth but also by altering the local cytokine and/ or angiogenic networks.

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