GC-MS Analysis, Hypoglycemic Activity of Aqueous Root Extract of Carica papaya and Its Effects on Blood Lipid Profile and Hepatorenal Tissues Biomarkers of Diabetic RatsSunday Ahamefula Ezekwe1 and Paul Chidoka Chikezie2*
- *Corresponding Author:
- Paul C Chikezie
Baskent Department of Biochemistry
Imo State University, Owerri, Nigeria
E-mail: [email protected]
Received date: May 03, 2017; Accepted date: May 10, 2017; Published date: May 17, 2017
Citation: Ezekwe SA, Chikezie PC (2017) GC-MS Analysis, Hypoglycemic Activity of Aqueous Root Extract of Carica papaya and Its Effects on Blood Lipid Profile and Hepatorenal Tissues Biomarkers of Diabetic Rats. J Diabetes Metab 8:740. doi:10.4172/2155-6156.1000740
Copyright: © 2017 Ezekwe SA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The likely phytocomponents, present in aqueous root extract (AqRE) of Carica papaya, responsible for hypoglycemic activity and their capacity to reverse altered blood lipid profile and compromised hepatorenal functions in alloxan-induced diabetic rats were investigated. The identification of main phytocomponents of AqRE of C. papaya was carried out using GC-MS system. The capacity of AqRE of C. papaya to reverse altered blood lipid profile and compromised hepatorenal functions were investigated using standard diagnostic techniques. The relative abundance of the 7 major phytocomponents present in AqRE of C. papaya was within the range of 3.49-35.63%. AqRE of C. papaya lowered elevated fasting blood glucose concentration of the diabetic rat group by 30.95%. The diabetic rat group treated with AqRE of C. papaya gave absolute values of TC-(HDL-C)]/(HDL-C=1.15 units, TC/ HDL-C=2.15 units and LDL-C/HDL-C=1.56 units. Additionally, the ratio of serum ALT to AST activities of the diabetic rat group treated with AqRE of C. papaya gave absolute value of 2.27 units. Serum total bilirubin, creatinine and urea concentrations of the diabetic rat group treated with AqRE of C. papaya were significantly lower (p<0.05) than that of diabetic rat group. GC-MS chromatogram of AqRE of C. papaya revealed the presence of phytochemicals of therapeutic potentials. AqRE of C. papaya ameliorated hyperglycemia and dyslipidemia in the diabetic rats. Finally, AqRE of C. papaya exhibited greater capacity to ameliorate obstructive liver dysfunction than hepatic tissue injuries in the diabetic rats.