alexa G-CSF: A Friend or Foe? | OMICS International | Abstract
ISSN: 1745-7580

Immunome Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

G-CSF: A Friend or Foe?

Ramya Sivakumar, Mark A Atkinson, Clayton E Mathews and Laurence Morel*

Department of Pathology, Immunology and Laboratory Medicine University of Florida, Gainesville, FL 32610, USA

*Corresponding Author:
Dr. Laurence Morel
Department of Pathology, University of Florida
1395 Center Drive, Gainesville, FL 32610-0275
Tel: (352) 273-5638
Fax: (352) 392-3053
E-mail: [email protected]

Received date: April 23, 2015; Accepted date: June 19, 2015; Published date: June 24, 2015

Citation: Sivakumar R, Atkinson MA, Mathews CE, Morel L (2015) G-CSF: A Friend or Foe? . Immunome Res S2:007. doi:10.4172/1745-7580.S2.007

Copyright: © 2015 Sivakumar, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Granulocyte colony stimulating factor (G-CSF) is an essential cytokine frequently used in clinics to restore myelopoiesis and facilitate peripheral mobilization of hematopoietic stem cells. Endogenously secreted G-CSF acts as a pleiotropic growth factor and mediates its biological functions [granulopoiesis] by binding specifically to granulocyte colony stimulating factor receptor (G-CSF-R). The G-CSF-G-CSF-R pathway known for its pro-Th2 and anti- inflammatory properties has been successful in reversing the course of diseases such as type 1 diabetes (T1D) and myelin basic protein-induced experimental autoimmune encephalomyelitis (MOG-EAE). The promising benefits of G-CSF have helped in establishing it as a successful candidate for several clinical trials. Even though cytokine based immune intervention offers a highly feasible and attractive option for immune disease control, caution needs to exerted on its usage as the functions of most cytokines vary depending upon the disease where they are applied, the research model being tested, as well as the modality of treatment (e.g., dose, duration and route) and, G-CSF despite its beneficial anti- inflammatory properties has also exerted bifurcated roles depending upon the disorder and dosage in which it’s applied.
This review aims to summarize the findings associated with the function and role of granulocyte colony-stimulating factor (G-CSF) and its dichotomous role in immune related therapies. Here we specifically focus on SLE and T1D, two autoimmune disorders in which G-CSF may exert physiological effects in opposite directions.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7